Tromantadine

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Tromantadine
Systematic (IUPAC) name
N-1-adamantyl-N-[2-(dimethylamino)ethoxy]acetamide
Identifiers
CAS number	53783-83-8
ATC code	D06BB02
PubChem	64377
Chemical data
Formula	C16H28N2O2
Mol. weight	280.406 g/mol
SMILES	O=C(C)N(OCCN(C)C)C23CC1CC(C3)CC(C2)C1
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	Topical

Tromantadine is an antiviral medicine used to treat herpes simplex virus. It is available in a topical gel under trade name Viru-Merz®. Its performance is similar to aciclovir.

Tromantadine inhibits the early and late events in the virus replication cycle. It changes the glycoproteins of the host cells, therefore impedes the absorption of the virus. It inhibits penetration of the virus. It also prevents uncoating of the virions.

Like rimantadine and amantadine, tromantadine is a derivate of adamantane.

See also [1]

Antivirals (primarily J05A, also S01AD and D06BB) edit

Anti-herpesvirus agents   Aciclovir, Cidofovir, Docosanol, Famciclovir, Fomivirsen, Foscarnet, Ganciclovir, Idoxuridine, Penciclovir, Trifluridine, Tromantadine, Valaciclovir, Valganciclovir, Vidarabine Anti-influenza agents Amantadine, Oseltamivir, Peramivir, Rimantadine, Zanamivir   Antiretroviral drugs   NRTIs Abacavir, Didanosine, Emtricitabine, Lamivudine, Stavudine, Zalcitabine, Zidovudine NtRTIs   Tenofovir NNRTIs   Efavirenz, Delavirdine, Nevirapine PIs Amprenavir, Atazanavir, Darunavir, Fosamprenavir, Indinavir, Lopinavir, Nelfinavir, Ritonavir, Saquinavir, Tipranavir Fusion inhibitors Enfuvirtide   Other antiviral agents Adefovir, Fomivirsen, Imiquimod, Inosine,Interferon, Podophyllotoxin, Ribavirin, Viramidine