Trimethobenzamide

From Wikipedia, the free encyclopedia

Trimethobenzamide is a medication frequently used as an antiemetic to prevent nausea and vomiting. Although the specific mechanism through which it functions is unknown, it is believed to effect the chemoreceptor trigger zone of the medulla oblongata. The mean half-life for trimethobenzamide is 7 to 9 hours. It is often prescribed for patients with the flu, medication-induced nausea, and other illnesses. Trimethobenzamide is generally considered the most potent antiemetic that does not have effects on the serotonergic, dopaminergic, or histaminergic systems, so it has a lower likelihood of causing undesired side effects. It is available as an oral capsule and a rectal suppository. In the United States, it requires a prescription.

Possible side effects include drowsiness, dizziness, headache, diarrhea, muscle cramps, and blurred vision.

Possible serious adverse effects include skin rash, tremors, Parkinsonism, and jaundice. If you experience these, contact your doctor immediately.

Trimethobenzamide is marketed under the brand names Tebamide and Tigan, manufactured by GlaxoSmithKline and King Pharmaceuticals, respectively.