Trifluoromethylphenylpiperazine

From Wikipedia, the free encyclopedia

Trifluoromethylphenylpiperazine

Chemical name	1-(3-(Trifluoromethyl)phenyl)piperazine
Other names	Trifluoromethylphenylpiperazine TFMPP
Chemical formula	C₁₁H₁₃F₃N₂
Molecular mass	230.23 g/mol
CAS number	[15532-75-9]
Density	? g/cm³
Melting point	? °C
SMILES	FC(F)(F)C1=CC(N2CCNCC2)=CC=C1
Disclaimer and references

Trifluoromethylphenylpiperazine (or simply TFMPP) is a piperazine-based drug, related to benzylpiperazine.

TFMPP was briefly emergency scheduled in Schedule I in the US, but the scheduling expired in April 2004 and has not been renewed. Therefore, unlike its cousin benzylpiperazine, TFMPP is not currently an illicit drug in the US.

It works as a serotonin receptor agonist in addition to releasing serotonin into the synapse. Due to the similar mode of action of ecstasy on the serotonin system, a mix of TFMPP and benzylpiperazine is sometimes advertised as a MDMA substitute. The subjective effects of this combination are often described as similar those of ecstasy, however without the empathic element. TFMPP seems to have little effect when not combined with benzylpiperazine, which explains the decision not to permanently make TFMPP an illicit drug.

Dosage for "ecstasy-like effects" would be between 80 and 130 mg.

[edit] Legal issues (outside USA)

TFMPP is off-white, yellowish in color.

Piperazine based products are classified as Prescription Only Medicines in the UK. Any products containing salts of the ingredient would be licensable under the Medicines Act and consequently anyone manufacturing and supplying it legally must hold the relevant licences to do so. As of December 3rd 2005, TFMPP is illegal in Denmark. As of March 1 2006, TFMPP is scheduled as a "dangerous substance" in Sweden.