Treatment of warts by keratolysis
From Wikipedia, the free encyclopedia
Keratolysis is the removal of dead surface skin cells and is a treatment for several types of wart. The most common keratolytic treatment of warts available over-the-counter involve salicylic acid. These products are readily available at most drugstores and supermarkets. There are typically two types of products: adhesive pads treated with salicylic acid, or a bottle of concentrated salicylic acid. Removing a wart with this method requires a strict regimen of cleaning the area, applying the salicylic acid, and removing the dead skin with a pumice stone or emery board. It may take up to 12 weeks to remove a stubborn wart.
Contents |
[edit] Formulations
Some formulations are:
- alcoholic solution containing glycerol
- collodion which dries to a celluloid film / Duofilm
- simple ointment
- absorption ointment
- oil in water cream
The amount of salicylic acid reaching the wart varies substantially depending on the formulation used
.[edit] Molecular basis of therapeutic effect
- salicylic acid reaches warts, lactic acid and collodion do not . Therefore these additional components have only an indirect role in therapy.
- the molecular structure of the skin is altered at the centre of the wart .
- experiments indicated that salicylic acid bonding within the human papillomavirus-containing verruca tissue is more likely than simple acid dissociation upon dissolution in water within the tissue .
[edit] Complications
Some cases of allergic contact dermatitis have been observed when using collodion formulationscolophony in the collodion.
. This was found to be due to[edit] References
- ↑ J Drug Target. 1998;5(5):343-51. PMID 9771616
- ↑ Int J Pharm. 1999 Oct 25;188(2):145-53. PMID 10518670
- ↑ Dermatol Clin. 1990 Jan;8(1):143-6. PMID 2302853
[edit] External Links
- List of brand names in U.S. and Canada [6]