Toremifene
From Wikipedia, the free encyclopedia
Toremifene
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Systematic (IUPAC) name | |
2-[4-(4-chloro-1, 2-diphenyl-but-1-enyl)phenoxy]- N,N-dimethyl-ethanamine | |
Identifiers | |
CAS number | 89778-26-7 |
ATC code | L02BA02 |
PubChem | 3005573 |
DrugBank | APRD00391 |
Chemical data | |
Formula | C26H28NClO |
Mol. weight | 405.959 g/mol |
Pharmacokinetic data | |
Bioavailability | ? |
Protein binding | more than 99.5% |
Metabolism | ? |
Half life | 5 days |
Excretion | ? |
Therapeutic considerations | |
Pregnancy cat. |
? |
Legal status | |
Routes | ? |
Toremifene citrate is an oral selective estrogen receptor modulator (SERM) which helps oppose the actions of estrogen in the body. Licensed in the United States under the brand name Fareston, toremifene citrate is FDA approved for use in advanced (metastatic) breast cancer. It is also being evaluated for prevention of prostate cancer under the brand name Acapodene.
[edit] Reference
- Price N, Sartor O, Hutson T, Mariani S. Role of 5a-reductase inhibitors and selective estrogen receptor modulators as potential chemopreventive agents for prostate cancer. Clin Prostate Cancer 2005;3:211-4. PMID 15882476.