Talk:Toll-like receptor

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This article needs to be merged with toll-like receptors. I'd advocate this articles removal, as the toll-like receptors plural is the form most encountered, and that article appears more up to date.

--ZZ 12:09, 9 Sep 2004 (UTC)

No, toll-like receptors should be merged here. Wikipedia article titles almost always use the singular form, not the plural form, see Wikipedia:Naming conventions (pluralization) unless they always appear in the plural form (which is not the case here). --Lexor|Talk 12:40, 9 Sep 2004 (UTC)

Ok thanks for that info.

I only joined yesterday, so I'm still finding my feet. I had a feeling that would be the case maybe.

--ZZ 23:58, 9 Sep 2004 (UTC)

Contents 1 13 or 11 2 Table 3 wrong link for PRR 4 individual TLRs 5 Reference section

[edit] 13 or 11

I just completed an essay about TLRs, and last I checked I only found 11 TLRs were identified in mammals; in fact a lot of classmates only managed to find out about 10 (little was known about 11 anayway). If anyone can come up with TLRs 12 & 13 I'd be willing to concede. Otherwise I'll change it to eleven on Monday.

There are other TLRs in non-mammalian vertebrates, but I'm sure that number would exceed 13 (counting ones identified in birds, goldfish, annelids and C. elegans etc) and its unsure if they should be TLRs-proper.

Check out Goldstein's reveiw on TLRs if you can get access to it.

--ZZ 08:22, 10 Sep 2004 (UTC)

Don't be afraid to be bold in updating pages, especially since you have a citation to back you up! I'm no expert in TLRs, and I noticed the inconsistency when I was trying to merge the two versions. I probably should have moved the inconsistent paragraph to the Talk here, until someone with more expertise had a chance to review it, but I was in a hurry... ;-) --Lexor|Talk 09:05, 10 Sep 2004 (UTC)

[edit] Table

Feel free to fix up that table for better-visualisation, or adding any other things that have been found recently. I'm planning on trying to incorporate as much information from my recent assignment into this article. Including what all that MyD88, TIRAP etc. stands for.--ZZ 05:53, 10 Oct 2004 (UTC) I think I might add the {{cleanup}} tag to this article

Table is fixed-up. --203.206.228.92 03:22, 15 Jun 2005 (UTC)

[edit] wrong link for PRR

Hi,

I just wanted to point out that the link to PRR (pattern recognition receptors) takes you to a page about Pennsylvania Railroads. I would have edited the link, but I am new here and couldn't figure out how to do it.

--Betty

[edit] individual TLRs

Should each TLR get their own entry, or should we just expound on the individuals one under different sections on this page?

Fhayashi 21:51, 24 April 2006 (UTC)

[edit] Reference section

I have removed this section from the article.

References are the papers, books, and websites that were actually USED in the article not just:

1. Some papers I like.
2. Some papers I wrote.
3. Some papers my boss/friend/underlings wrote.

These papers were NOT used to write this article and have way too many things in common to have been used by an impartial editor (except for ref number 4, and maybe the reveiws). I can think of a dozen or so more influential papers. See also WP:COI.

If these are in fact refs, they need to be referenced "in-line" (see WP:CITE).

I apologize if I have removed any legitimate refs, feel free to add them back in, using a proper citation method. Again, WP:CITE. --DO11.10 21:34, 28 October 2006 (UTC)

References

Medzhitov,R., Preston-Hurlburt,P., and Janeway,C.A., Jr. 1997. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity [see comments]. Nature 388:394-397.

Recent review articles on the TLRs:

• Genetic analysis of host resistance: Bruce Beutler, et al., "Toll-like receptor signaling and immunity at large." Annu Rev Immunol. 2006;24:353-89
• Daniel R Goldstein, "Toll-like receptors and other links between innate and acquired alloimmunity", Current Opinion in Immunology 16(5):538-544, October 2004 (DOI:10.1016/j.coi.2004.08.001)
• Luke A. J. O'Neill, "Immunity's Early-Warning System", Scientific American 292(1):38-45, January 2005
• Dunne A, O'Neill LA, "The interleukin-1 receptor/Toll-like receptor superfamily: signal transduction during inflammation and host defense", Sci STKE. 2003 Feb 25;2003(171):re3. online version

• • No I used them in making the article. Wouldn't it make sense to check with the people who added the references?--ZayZayEM 06:15, 22 November 2006 (UTC)

It was not that reference that I was talking about, it was this edit when User:66.91.232.161 put a very long list of "references" with the following header:

Many thousands of papers have been published in the TLR field. A very small sampling of original articles pertaining the the identification of TLRs and discovery of their function follows:. That just screams "I know these people and I want to promote their papers."

I apologize if your reference got caught up in this. Actually the "review" articles look okay (which I can see that your ref was part of), I will add them, and the Janeway article, back into the article.--DO11.10 18:11, 22 November 2006 (UTC)