TNA (nucleic acid)
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TNA is threose nucleic acid, a chemical similar to DNA or RNA but differing in the composition of its "backbone." TNA is not known to occur naturally in existing life on Earth.
DNA and RNA have a deoxyribose and ribose sugar backbone, respectively, whereas TNA's backbone is composed of repeating threose units linked by peptide bonds. The threose molecule is easier to assemble than ribose making it a possible precursor to RNA.
DNA TNA hybrid chains have been made in the laboratory using DNA polymerase.
[edit] External links
- Was simple TNA the first nucleic acid on Earth to carry a genetic code? - New scientist
- ORIGIN OF LIFE: A Simpler Nucleic Acid - Leslie Orgel
[edit] References
- Orgel, Leslie (Nov 2000). "A Simpler Nucleic Acid". Science 290 (5495): 1306 - 1307. DOI:10.1126/science.290.5495.1306.
- Watt, Gregory (Feb 2005). "Modified nucleic acids on display". Nature Chemical Biology. DOI:10.1038/nchembio005.
- Schoning, K, Scholz P; Guntha S; Wu X; Krishnamurthy R; Eschenmoser A (Nov 2000). "Chemical etiology of nucleic acid structure: the alpha-threofuranosyl-(3'->2') oligonucleotide system.". Science. PMID 11082060.
Nucleic acids and oligonucleotides edit | ||
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Nucleobases: | Adenine | Thymine | Uracil | Guanine | Cytosine | Purine | Pyrimidine | |
Nucleosides: | Adenosine | Uridine | Guanosine | Cytidine | Deoxyadenosine | Thymidine | Deoxyguanosine | Deoxycytidine | |
Nucleotides: | AMP | UMP | GMP | CMP | ADP | UDP | GDP | CDP | ATP | UTP | GTP | CTP | cAMP | cADPR | cGMP | |
Deoxynucleotides: | dAMP | TMP | dGMP | dCMP | dADP | TDP | dGDP | dCDP | dATP | TTP | dGTP | dCTP | |
Ribonucleic acids: | RNA | mRNA | tRNA | rRNA | ncRNA | sgRNA | shRNA | siRNA | snRNA | miRNA | snoRNA | LNA | |
Deoxyribonucleic acids: | DNA | mtDNA | cDNA | plasmid | Cosmid | BAC | YAC | HAC | |
Analogues of nucleic acids: | GNA | PNA | TNA| LNA | morpholino | |
←Amino acids | Major families of biochemicals | Carbohydrates→ |