Tipranavir

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Tipranavir chemical structure
Tipranavir
Systematic (IUPAC) name
N-[3-[1-(2-hydroxy-4-oxo-6- phenethyl-6-propyl-5H-pyran-3-yl) propyl] phenyl] quinoline- 8-sulfonamide
Identifiers
CAS number 174484-41-4
ATC code J05AE09
PubChem 65027
DrugBank APRD01306
Chemical data
Formula C31H33N2F3O5S 
Mol. weight 584.726 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life 5-6 hours
Excretion  ?
Therapeutic considerations
Licence data

EU US
Pregnancy cat.

?
Legal status
Routes  ?

Tipranavir, or tipranavir disodium, is a nonpeptidic protease inhibitor (PI) with the trade name Aptivus®. It is used in combination therapy to treat HIV infection.

Tipranavir has the ability to inhibit the replication of viruses that are resistant to other protease inhibitors. Resistance to tipranavir itself seems to require multiple mutations.[1] Tipranavir is given in combination with ritonavir 200 mg twice daily.

Tipranavir was approved by the Food and Drug Administration (FDA) on June 22, 2005. Nelfinavir is the only other FDA approved nonpeptidic protease inhibitor. Like lopinavir and atazanavir, it is very potent and is effective in salvage therapy for patients with some drug resistance. However, it tends to have more side effects.

[edit] References

  1. ^ Doyon L, Tremblay S, Bourgon L, Wardrop E, Cordingley M (2005). "Selection and characterization of HIV-1 showing reduced susceptibility to the non-peptidic protease inhibitor tipranavir.". Antiviral Res 68 (1): 27-35. PMID 16122817. Retrieved on 2006-01-20.
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Antivirals (primarily J05A, also S01AD and D06BB) edit
Anti-herpesvirus agents   Aciclovir, Cidofovir, Docosanol, Famciclovir, Fomivirsen, Foscarnet, Ganciclovir, Idoxuridine, Penciclovir, Trifluridine, Tromantadine, Valaciclovir, Valganciclovir, Vidarabine
Anti-influenza agents Amantadine, Oseltamivir, Peramivir, Rimantadine, Zanamivir
 
Antiretroviral drugs   NRTIs Abacavir, Didanosine, Emtricitabine, Lamivudine, Stavudine, Zalcitabine, Zidovudine
NtRTIs   Tenofovir
NNRTIs   Efavirenz, Delavirdine, Nevirapine
PIs Amprenavir, Atazanavir, Darunavir, Fosamprenavir, Indinavir, Lopinavir, Nelfinavir, Ritonavir, Saquinavir, Tipranavir
Fusion inhibitors Enfuvirtide
 
Other antiviral agents Adefovir, Fomivirsen, Imiquimod, Inosine,Interferon, Podophyllotoxin, Ribavirin, Viramidine
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