Ticlopidine
From Wikipedia, the free encyclopedia
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Ticlopidine
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| Systematic (IUPAC) name | |
| 3-[(2-chlorophenyl)methyl] -7-thia-3-azabicyclo[4.3.0] nona-8,10-diene | |
| Identifiers | |
| CAS number | 55142-85-3 |
| ATC code | B01AC05 |
| PubChem | 5472 |
| DrugBank | APRD01257 |
| Chemical data | |
| Formula | C14H14NClS |
| Mol. weight | 263.786 g/mol |
| Pharmacokinetic data | |
| Bioavailability | >80% |
| Protein binding | 98% |
| Metabolism | Hepatic |
| Half life |
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| Excretion | Renal and fecal |
| Therapeutic considerations | |
| Pregnancy cat. | |
| Legal status | |
| Routes | Oral |
Ticlopidine (trade name Ticlid) is an antiplatelet drug in the thienopyridine family. Like clopidogrel, it is an adenosine diphosphate (ADP) receptor inhibitor. It is used in patients in whom aspirin is not tolerated, or in whom dual antiplatelet therapy is desirable. Because it has been reported to increase the risk of thrombotic thrombocytopenic purpura (TTP) and neutropenia, its use has largely been supplanted by the newer drug, clopidogrel, which is felt to have a much lower hematologic risk. The usual dose is 250mg twice daily by the oral route.
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[edit] Action
- Inihibits platelet aggregation by altering the function of platelet membranes.
- Prolongs bleeding time.
- Decreased incidence of stroke in high-risk patients.
[edit] Contraindications
- Hypersensitivity
- Bleeding disorders
- Active bleeding
- Severe liver disease
[edit] Precautions
- Risk of bleeding (trauma, surgery, history of peptic ulcer disease)
- Renal or hepatic impairment
- Geriatric patients (increased sensitivity)
- Pregnancy, lactation, or children under 18
[edit] Adverse Reactions and Side Effects
- Central Nervous System: anxiety, drowsiness, fatigue, insomnia, nervousness, syncope, vertigo, weakness.
- Ear, Eye, Nose, Throat: cataracts, conjunctivitis, glaucoma, pharyngitis, rhinitis, sinusitis.
- Respiratory: bronchitis.
- Cardiovascular: chest pain, dependent edema, hypertension, peripheral edema.
- Gastrointestinal: abdominal pain, anorexia, constipation, diarrhea, dry mouth, dysphagia, esophageal ulcer, esophagitis, flatulence, gastric ulcer, gastritis, nausea, vomiting.
- Genitourinary: urinary tract infection.
- Dermatologic: flushing, sweating, pruritus, rash (including Stevens-Johnson syndrome), skin disorders.
- Endocrine: hyperparathyroidism.
- Fluid and Electrolyte: hypocalcemia.
- Musculoskeletal: arthrosis, myositis, abnormal muscle contractions, pathological fractures.
- Neurological: paresthesia.
- Miscellaneous: infection.
[edit] Route and Dosage
- Adults: 400 mg/day taken with 8oz of plain water only, for 3 months.
