Tiaprofenic acid

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Tiaprofenic acid chemical structure
Tiaprofenic acid
Systematic (IUPAC) name
5-Benzoyl-α-methyl-2-thiopheneacetic acid
Identifiers
CAS number 33005-95-7
ATC code M01AE11
PubChem 5468
Chemical data
Formula C14H12O3S
Mol. weight 260.309
Pharmacokinetic data
Bioavailability 90%
Metabolism 10% hepatic
Half life 1.5-2.5h
Excretion 50-80% urine
Therapeutic considerations
Pregnancy cat.

C
Legal status

POM
Routes oral

Tiaprofenic acid is a non-steroidal anti-inflammatory drug of the arylpropionic acid (profen) class, used to treat pain, especially arthritic pain. The typical adult dose is 300mg twice daily. It is not recommended in children.

It is sparingly metabolised in the liver to two inactive metabolites. Most of the drug is eliminated unchanged in the urine. Renal disease impairs excretion, and it should be used with caution in renal disease.

Longterm use of tiaprofenic acid is associated with severe cystitis, roughly 100 times more commonly than other NSAIDs. It is contraindicated in patients with cystitis and urinary tract infections.

It is marketed under the trade names Surgam, Surgamyl and Tiaprofen, and in generic formulations. A sustained-release preparation is available.

[edit] References

  • Crawford MLA, Waller PC, Wood SM. Severe cystitis associated with tiaprofenic acid. British Journal of Urology 1997; 79(4): 578-584.

[edit] External links

  • Manufacturer Data Sheet [1]


Non-steroidal anti-inflammatory drugs (primarily M01A and M02A, also N02BA) edit

Salicylates: Aspirin (Acetylsalicylic Acid), Diflunisal, Ethenzamide -- Arylalkanoic acids: Diclofenac, Indometacin, Sulindac

2-Arylpropionic acids (profens): Carprofen, Flurbiprofen, Ibuprofen, Ketoprofen, Ketorolac, Loxoprofen, Naproxen, Tiaprofenic acid,

N-Arylanthranilic acids (fenamic acids): Mefenamic acid -- Pyrazolidine derivatives: Phenylbutazone

Oxicams: Meloxicam, Piroxicam -- Coxibs: Celecoxib, Etoricoxib, Parecoxib, Rofecoxib, Valdecoxib -- Sulphonanilides: Nimesulide

Topically used products: Diclofenac, Flurbiprofen, Ibuprofen, Indometacin, Ketoprofen, Naproxen, Piroxicam


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