Tiagabine

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Tiagabine
Systematic (IUPAC) name
(3S)-1-[4,4-bis(3-methylthiophen-2-yl)but-3-enyl] piperidine-3-carboxylic acid
Identifiers
CAS number	115103-54-3
ATC code	N03AG06
PubChem	60648
DrugBank	APRD00344
Chemical data
Formula	C20H25NO2S2
Mol. weight	375.55 g/mol
Pharmacokinetic data
Bioavailability	90%
Protein binding	96%
Metabolism	Hepatic (CYP450 system)
Half life	7-9 hours
Excretion	Fecal and renal
Therapeutic considerations
Pregnancy cat.	B3 (Au), C (U.S.)
Legal status	POM (UK), ℞-only (U.S.)
Routes	Oral

Tiagabine (IPA: [ˌtɪəgəˈbin]) is an anti-convulsive medication produced by Cephalon Inc. and marketed under the brand name Gabitril®. The medication is also used in the treatment for panic disorder as are a few other anticonvulsants.

Though the exact mechanism by which tiagabine exerts its effect on the human body is unknown, it does appear to operate as a selective GABA reuptake inhibitor.

[edit] Side effects

Tiagabine's most common side effects include confusion, difficulty speaking clearly/stuttering, mild sedation, and in doses over 8mg, a tingling sensation (paraphasia) in the body's extremities, particularly the hands and fingers.

[edit] External links

• Gabitril (manufacturer's website)
• Tiagabine (patient information)

Anticonvulsants (N03) edit

Barbiturates: Barbexaclone, Metharbital, Methylphenobarbital, Phenobarbital, Primidone Hydantoins: Ethotoin, Fosphenytoin, Mephenytoin, Phenytoin -- Oxazolidinediones: Ethadione, Paramethadione, Trimethadione Succinimides: Ethosuximide, Mesuximide, Phensuximide Benzodiazepines: Clobazam, Clonazepam, Clorazepate, Diazepam, Lorazepam, Midazolam, Nitrazepam, Temazepam Carboxamides: Carbamazepine, Oxcarbazepine, Rufinamide -- Fatty acid derivatives: Valpromide, Valnoctamide Carboxylic acids: Valproic acid (Sodium valproate & Valproate semisodium), Tiagabine -- GABA analogs: Gabapentin, Pregabalin, Progabide, Vigabatrin Others:- Monosaccharides: Topiramate -- Aromatic allylic alcohols: Stiripentol -- Ureas: Phenacemide, Pheneturide -- Phenyltriazines: Lamotrigine Carbamates: Emylcamate, Felbamate, Meprobamate -- Pyrrolidines: Brivaracetam, Levetiracetam, Nefiracetam, Seletracetam Sulfa drugs: Acetazolamide, Ethoxzolamide, Sultiame, Zonisamide -- Propionates: Beclamide -- Aldehydes: Paraldehyde -- Bromides: Potassium bromide, Sodium bromide