Thyronamine

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Thyronamines are decarboxylated and deiodinated metabolites of the thyroid hormones thyroxine (T4) and 3,5,3'-triiodothyronine (T3).

The thyronamine 3-iodothyronamine (T1AM) is a natural, high-affinity ligand for the trace amine-associated receptor TAAR1 (TAR1, TA1), a G protein-coupled receptor. In rodents, T1AM causes a rapid drop in body temperature when injected.

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[edit] References

  • Nat. Med. 10(6):638-642 (2004) 3-Iodothyronamine is an endogenous and rapid-acting derivative of thyroid hormone PMID 15146179
  • J. Med. Chem. 49(3):1101-1112 (2006) Trace amine-associated receptor agonists: synthesis and evaluation of thyronamines and related analogues PMID 16451074
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