Thrombin-activatable fibrinolysis inhibitor
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carboxypeptidase B2
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| Identifiers | |
| Symbol(s) | CPB2 |
| Entrez | 1361 |
| OMIM | 603101 |
| RefSeq | NM_001872 |
| UniProt | Q96IY4 |
| Other data | |
| Locus | Chr. 13 q14.11 |
Thrombin-activatable fibrinolysis inhibitor (TAFI), also known as plasma carboxypeptidase B2 is a recently described plasma zymogen that, when exposed to the thrombin-thrombomodulin complex, is converted by proteolysis at Arg92 to a basic carboxypeptidase (TAFIa or activated TAFI) that inhibits fibrinolysis. TAFI is produced by the liver.
[edit] External link
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| Coagulation factors: - Fibrin (I) - (Pro)thrombin (II) - FV - FVII - FVIII - FIX - FX - FXI - FXII - FXIII - HMWK - vWF - Tissue factor |
| Inhibitors: Antithrombin - Protein C - Protein S - Protein Z - ZPI - TFPI |
| Fibrinolysis: Plasmin - tPA/urokinase - PAI-1/2 - α2-AP - TAFI |
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