Talk:Thrombotic thrombocytopenic purpura

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[edit] Relation with contraception

Both references that were included for the statement that there is a relation between anticonception use and TTP conclude that: a causal relationship between progestogen-only contraceptives and TTP is not established by the data presented. So I don't think it should be included in this article unless new hard evidence becomes available. The first study also had some follow-up letters disputing its claims. The references:

  • Wysowski DK, Green L (1995). "Serious adverse events in Norplant users reported to the Food and Drug Administration's MedWatch Spontaneous Reporting System". Obstet Gynecol 85 (4): 538-42. PMID 7898829.
  • Fraser JL, Millenson M, Malynn ER, Uhl L, Kruskall MS (1996). "Possible association between the Norplant contraceptive system and thrombotic thrombocytopenic purpura". Obstet Gynecol 87 (5 Pt 2): 860-3. PMID 8677116.

--WS 05:14, 15 January 2006 (UTC)

While I agree with you that causality has never been proven, I think that the controversy is sufficiently important (and interesting) that it should be mentioned somewhere in the article. Mgmei 05:21, 15 January 2006 (UTC)
A total of 3 reported cases ever worldwide is hardly even controversial. The reported rate was not even higher than in women who didn't use norplant. It was the authors estimation (no evidence given) that it was underreported and therefore the actual rate could be actually higher. If you really want to add that to the article that's fine with me, but choose your words carefully and certainly don't state it as a fact and also for nothing else than norplant. --WS 05:35, 15 January 2006 (UTC)

I agree with WS here. Just because TTP is rare does not mean all theoretical links should be farmed out over here. Ticlopidine, now that's a different matter. JFW | T@lk 14:15, 16 January 2006 (UTC)

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