Talk:Thiazolidinedione

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approved for use in Type II diabetes

is use for PCOS approved? JWSchmidt 19:26, 21 Apr 2004 (UTC)

Not to my knowledge, but in several studies it proved very beneficial (like metformin, confirming again that insulin resistance is very central in PCOS; e.g. MedScape. JFW | T@lk 19:29, 21 Apr 2004 (UTC)

Does Wikipedia have any kind of policy about trying to indicate which uses for drugs are approved uses? JWSchmidt 17:27, 22 Apr 2004 (UTC)

Uhh—I'm reluctant to admit that I don't know what the main source for "Wikipedia policy" is. IMHO, this shouldn't be an issue, as "approval" differs between one country and the next. In the UK, it is at the discretion of the prescribing doctor to prescibe off-licence drugs (many do it, few admit it). As stated, I have not seriously looked into registration of thiazolidinediones for NASH and PCOS. If you feel this is important, please let me know. JFW | T@lk 19:23, 22 Apr 2004 (UTC)

[edit] Rosiglitazone for Alzheimer's

NIH funded a drug trial to test rosiglitazone in a controlled study with sugar pill one group and drug in another, etc. 18-month. MRI will be done to start off and at end of study.

Point is insulin may affect protein levels that make up the sticky plaques in the brains of people with Alzheimer's disease. I am not a participant in the pilot Seattle VA study.

Improving how the body uses insulin is a long term goal; maybe will help slow progress of memory loss.