User talk:Techelf

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Hello Techelf, welcome to Wikipedia. Here's some tips:

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I hope you enjoy editing here and being a Wikipedian! Angela. 10:23, Apr 4, 2004 (UTC)

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Contents 1 ACE inhibitor 2 cytochrome p450 3 Omeprazole structure 4 Esomeprazole structure 5 Imatinib 6 Trimethoprim 7 Drug addiction vs drug dependence 8 Article Licensing 9 :-) 10 Ibuprofen vs. aspirin 11 Diuretics 12 Drug dependence 13 Bupe 14 St Johns Wort 15 Thanks! 16 Pharmacist edits 17 Vancomycin 18 Tramadol 19 Levobupivacaine 20 Dihydrocodeine 21 Orphaned fair use image (Image:M2mwy logo.jpeg) 22 Template 23 Metroad markers 24 Cephalosporin template 25 Beclomethasone and Beclomethasone propionate 26 Naproxen schedules 27 Drug legal status 28 Copyright notification 29 Image:Nizatidine.png 30 Drawing chemical structures

[edit] ACE inhibitor

Congrats on your nice work on captopril and ACE inhibitor. I'm curious what your field is; you a pharmacologist/pharmacists by any chance? There's a WikiProject "Drugs", and I was wondering if you'd like to join & participate. JFW | T@lk 10:05, 27 Jun 2004 (UTC)

Welcome to the WikiProject. Wikipedia could use some drug people (and as a doctor I know too little to write up all those nice pills we prescribe...) Yes, I should have looked at your user profile... JFW | T@lk 10:34, 27 Jun 2004 (UTC)

Hi. I would like to ask why do you think the Captopril issue isn't a stub, since it lacks some things I, as a nurse, consider real important like side-effects and contra-indications?. Forget it. Just clicked the link for clinical use ;) By the way, great job on what is already done! Ricardo Silva 17:10, 5 January 2006 (UTC)

[edit] cytochrome p450

Thanks for the cleanup. Alteripse 12:43, 20 Sep 2004 (UTC)

[edit] Omeprazole structure

Hello,
your omeprazole structure formula seems to be not correct. You have there methoxydimethylphenyl group, which should be methoxydimethylpyridyl.. Could you please fix it? Regards, Mykhal 10:26, 4 Oct 2004 (UTC)

You're right about the structure, and I've fixed it. Thanks for pointing that out. Incidentally, the Losec® Approved Product Information in Australia (sourced from E-MIMS) has the wrong structure; as that was what I based my sketch on (without checking). I've also fixed up the structure of esomeprazole. Techelf 14:29, 4 Oct 2004 (UTC)

[edit] Esomeprazole structure

Hi, I have recently noticed, that your esomeprazole structure has wrong stereochemistry. It is actually an R isomer, not S. Please fix it. Mykhal 21:54, 20 Oct 2004 (UTC)

What I have drawn is, actually, the correct structure of S-omeprazole. The S designation of this molecule is with respect to its structure in vivo - where the sulfinyl moiety is ionised, and there is an additional hydrogen substituent off the chiral sulfur. Under these circumstances the stereochemistry is clearly S. So whilst, technically, this drawing may be R, it actually does represent the structure of S-omeprazole.

Also, with regards to the "di" that I had accidentally placed in front of the structural formulae of omeprazole and esomeprazole, these were oversights when I was transposing the name from the proprietary preparation "di-5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl] sulfinyl]-1H-benzimidazole magnesium trihydrate". I had overlooked the fact that the "di" referred to the whole molecule and forgot to remove it. But thanks for noticing that - one of those small details that I wouldn't otherwise have noticed.

After all, I'm a pharmacy student, not a "chemist". =) Techelf 11:10, 21 Oct 2004 (UTC)

I do not agree/understand your explanation. The drug is a chemical compound, the structure should be the one representing the substance present in the bottle. We know the structure of omeprazole. It is a chiral compound, it has asymmetric sulfur atom (sulfoxide). It can be R or S.. according to databases, esomeprazole has S configuration .. your of esomeprazole has R. Please correct me if I'm wrong somewhere :) Mykhal 21:54, 21 Oct 2004 (UTC)

You might make mistake when copying the structure - you probably flipped the oxygen atom down but have forgotten to invert the stereo bond.. Mykhal 11:59, 22 Oct 2004 (UTC)

I concede the point and have revised the drawing accordingly. I had initially (wrongly) supposed that the orientation of the substituents off the chiral sulfur was of a trigonal planar configuration; therefore I had assumed that the orientation of the oxygen substituent would not make a difference. In retrospect, I've realised that the sulfur substituents have a tetrahedral configuration; so you are right about the oxygen substituent being inverted - well spotted. Techelf 06:46, 23 Oct 2004 (UTC)

I know, this is not obvious, that on the sulfur atom is lone electron pair which is the fourth "substituent" with lowest priority.. Thank you for the immediate action. Mykhal 08:54, 23 Oct 2004 (UTC)

[edit] Imatinib

What problem are you trying to solve by adding <br> tags to the long chemical name in the Imatinib article? I would have expected that just letting the browser break the long word would be sufficient. What browser did the wrong thing, and what did it do wrong? —AlanBarrett 18:24, 5 Nov 2004 (UTC)

Hi Alan, the purpose of the <br> tags is mainly for Gecko-based browser (Mozilla, Firefox, Netscape, Camino, etc) which, for some reason, don't seem to break at hyphens in any of the longer IUPAC names I've entered into Wikipedia drug infoboxes; so the drugbox can sometimes become wider than the entire screen. Gecko-based browsers do break at spaces, though, which is why I had those spaces in the name - but the <br> solution probably looks more accurate to more people. It seems to work out okay this way for Internet Explorer, but it does look a bit strange in Safari - probably just needs a bit of tweaking with regards to where the linebreak is placed. I haven't had a chance to test it out in Opera yet unfortunately. Techelf 13:09, 6 Nov 2004 (UTC)

I usually use Opera, and it breaks the line at hyphens. I just tried Firefox, and it does not break at hyphens. I suppose the explicit <br> tags are better than the bad browser behaviour. —AlanBarrett 15:53, 6 Nov 2004 (UTC)

[edit] Trimethoprim

Hi, Kieren. Could you take another look at your diagram in the article trimethoprim, please? I think that sulfonamides block dihydropteroate synthase, not reductase. Axl 16:05, 15 Nov 2004 (UTC)

Yep, you're right. I've uploaded the fixed diagram. Techelf 06:15, 16 Nov 2004 (UTC)

Er, the picture still says 'reductase' when I view it. By the way, would you like to add your name to the Wikipedia:WikiProject Clinical medicine page? Axl 10:29, 17 Nov 2004 (UTC)

[edit] Drug addiction vs drug dependence

Hi Techelf :) Sure, I believe that it is a very important distinction to make, especially with current medical situation of pain management. Patients are made to suffer unneccessarily while physicians fear prosecution, (or that their patients will become addicted). The vast majority of patients who come to use opioids have no problems stopping when the pain is healed (despite withdrawal symptoms), and why is there a concern of addiction for patients with chronic pain? If their pain is not going to go away, why worry that they will have problems ceasing use of opioids? I'd certainly like to hear your opinions on this subject. --Thoric 03:37, 6 Dec 2004 (UTC)

[edit] Article Licensing

Hi, I've started a drive to get users to multi-license all of their contributions that they've made to either (1) all U.S. state, county, and city articles or (2) all articles, using the Creative Commons Attribution-Share Alike (CC-by-sa) v1.0 and v2.0 Licenses or into the public domain if they prefer. The CC-by-sa license is a true free documentation license that is similar to Wikipedia's license, the GFDL, but it allows other projects, such as WikiTravel, to use our articles. Since you are among the top 2000 Wikipedians by edits, I was wondering if you would be willing to multi-license all of your contributions or at minimum those on the geographic articles. Over 90% of people asked have agreed. For More Information:

• Multi-Licensing FAQ - Lots of questions answered
• Multi-Licensing Guide
• Free the Rambot Articles Project

To allow us to track those users who muli-license their contributions, many users copy and paste the "{{DualLicenseWithCC-BySA-Dual}}" template into their user page, but there are other options at Template messages/User namespace. The following examples could also copied and pasted into your user page:

Option 1

I agree to [[Wikipedia:Multi-licensing|multi-license]] all my contributions, with the exception of my user pages, as described below:

{{DualLicenseWithCC-BySA-Dual}}

OR

Option 2

I agree to [[Wikipedia:Multi-licensing|multi-license]] all my contributions to any [[U.S. state]], county, or city article as described below:

{{DualLicenseWithCC-BySA-Dual}}

Or if you wanted to place your work into the public domain, you could replace "{{DualLicenseWithCC-BySA-Dual}}" with "{{MultiLicensePD}}". If you only prefer using the GFDL, I would like to know that too. Please let me know what you think at my talk page. It's important to know either way so no one keeps asking. -- Ram-Man (comment| talk)

[edit]  :-)

No worries, you deserve the barnstar :-) Ta bu shi da yu 11:57, 14 Dec 2004 (UTC)

[edit] Ibuprofen vs. aspirin

Kieren, I wonder if you have anything further to say about these questions from Dan100? Thanks. Axl 15:38, 21 Dec 2004 (UTC)

[edit] Diuretics

I just wanted to say that I agree wholeheartadly that Wikipedia needs some serious work on diuretics pages. I've been wanting to put some work into it for some time but somehow I never seem to have the time to get around to it.

Do you think it would be worth while to get some basic info up and then let people fill in the details or would it be better to do one page (thouroughly) at a time?

--Selket 05:59, 15 Mar 2005 (UTC)

[edit] Drug dependence

I saw your comments on Thoric's talk page, and I'm basically interested in the same issue. I would also like to get your opinion on the drug abuse article and where you think it should go. --Viriditas | Talk 22:57, 13 Apr 2005 (UTC)

Thanks for getting back to me. --Viriditas | Talk 11:15, 18 Apr 2005 (UTC)

[edit] Bupe

Hi! Thanks for shaking up the buprenorphine article, though you've deleted a lot of good information that I've reintegrated selectively and reformatted. The addiction treatment section still does need more work, but I'm glad you started chipping away at it... —Tarnas 20:07, 21 August 2005 (UTC)

Agreed, I was probably a bit too zealous in my content deletion. The edits look good. Cheers. -Techelf 12:08, 22 August 2005 (UTC)

[edit] St Johns Wort

Excellent edit, with good sourcing. I see from discussion above that you seem to make a habit of it! --Red King 23:35, 22 November 2005 (UTC)

[edit] Thanks!

Hi Techelf, thanks for the compliments! I figured that I should contribute to Wikipedia after using it so much, and I've noticed your excellent edits here and there... including your excellent user page which I adopted as a template :-) Uthbrian 23:49, 9 December 2005 (UTC)

[edit] Pharmacist edits

Thanks for fixing the introductory paragraph. I was reading the new text an anonymous user added yesterday and felt it was too biased for a general article on pharmacists to focus on the PharmD in the first paragraph. I was trying to think of something that would more NPOV and you came up with the right words. Simplesse 04:12, 6 January 2006 (UTC)

No worries. =) -Techelf 08:44, 6 January 2006 (UTC)

[edit] Vancomycin

It appears that the structure graphic is incorrect - compare to the PubChem reference, and this NIH graphic noted in the vancomycin discussion page. I concede there is a significant amount of confusion in the literature on the specifics of the strucure however. --TechChem 19:39, 8 February 2006 (UTC)

Thanks, I've updated the structure. -Techelf 10:40, 10 February 2006 (UTC)

[edit] Tramadol

Thanks for tidying up my recent tramadol edit, but are you certain that " both enantiomers found to inhibit reuptake of 5-HT and noradrenaline". My understanding is that the + was mu and SRI and (-) was NA RI only. A review of my references suggests that the (-) is "mainly" NRI...

"(+/-)-Tramadol is a selective agonist of mu receptors and preferentially inhibits serotonin reuptake, whereas (-)-tramadol mainly inhibits noradrenaline reuptake."

Pharmacology of Tramadol, Dayer P, Desmeules J, Collart L, Service de Pharmacologie Cliniqu et Consultation de la Douleur Hospital Cantonal Universitaire, Geneva, Suisse. Drugs 1997; 53 Suppl 2:18-24 bignoter 11:47, 9 March 2006 (UTC)

Thanks for the message. Things are never simple in pharmacology, unfortunately. =) I had a quick look at the Micromedex Drugdex monograph, which quotes details from a review by Shipton (2000) (PMID 10969362):

1. The (+) enantiomer of tramadol and its major metabolite bind more strongly to the mu-opioid receptor than the respective (-) enantiomers
2. The opioid and 5-hydroxytryptamine (serotonin) reuptake inhibitory effect is about 4 times more potent in the (+) enantiomer, whereas the noradrenaline reuptake inhibitory effect is in the (-) enantiomer

So I guess you're right about NAd reuptake, but both enantiomers have some μ-opioid and 5-HT reuptake activity. I'll update the article to reflect this information. -Techelf 10:40, 10 March 2006 (UTC)

Hi Re analgesic etc see 1. Susce, M.T., E. Murray-Carmichael, and J. de Leon, Response to hydrocodone, codeine and oxycodone in a CYP2D6 poor metabolizer. Prog Neuropsychopharmacol Biol Psychiatry, 2006. 2. Slanar, O., et al., Miotic action of tramadol is determined by CYP2D6 genotype. Physiol Res, 2006. 3. Pedersen, R.S., P. Damkier, and K. Brosen, Enantioselective pharmacokinetics of tramadol in CYP2D6 extensive and poor metabolizers. Eur J Clin Pharmacol, 2006. 62(7): p. 513-21. 4. Enggaard, T.P., et al., The analgesic effect of tramadol after intravenous injection in healthy volunteers in relation to CYP2D6. Anesth Analg, 2006. 102(1): p. 146-50.

Also More recent SERT data re tramadol [1-3]. So, a single 100 mg dose of tramadol produces peak plasma concentrations of ~ 300 ng/ml, equivalent to about 1 µM conc. that suggests tramadol might have some (small) effect on serotonin transporter (SERT). References 1. Lomenzo, S.A., et al., Synthesis and Biological Evaluation of Meperidine Analogues at Monoamine Transporters. J Med Chem, 2005. 48(5): p. 1336-1343. 2. Barann, M., et al., Effects of tramadol and O-demethyl-tramadol on human 5-HT reuptake carriers and human 5-HT3A receptors: a possible mechanism for tramadol-induced early emesis. Eur J Pharmacol, 2006. 531(1-3): p. 54-8. 3. Rothman, R.B. and M.H. Baumann, Therapeutic Potential of Monoamine Transporter Substrates. Current Topics in Medicinal Chemistry, 2006. 6: p. 1845-1859. Ken Gillman 03:05, 23 September 2006 (UTC)

My thought would be why on earth would one use such rotten toxic weak serotonin reuptake inhibitor as this when we've got much more specific and potent drugs. Just sniffing a tablet of Sertraline would probably generate a more reuptake inhibition than tramadol. Ken Gillman 03:05, 23 September 2006 (UTC)

And- who put up the serotonin toxicity table. I would like to help update it. But a perspective from www.psychotropical.com (my website- which will be updated even more v soon (like ~ 2 weks)) would help as background reading (the refs to the papers I have published re serotonin toxicity may be seen there too) I suggest tertiary references like the Australian Medicines Handbook and the British National Formulary etc are not ideal reference sources for an up tp data analysis. I can send you Ian Whytes papers, as well as my own. We, Australians, have really lead the way in this area; but not via the AMH I fear. Ken Gillman 03:05, 23 September 2006 (UTC)

[edit] Levobupivacaine

Hi, I think you may have gotten the structure of levobupivacaine wrong. I have the production information sheet from the box, and the structure that is drawn by the manufacturer is exact mirror image of the picture you drawn. (i.e. Your picture may actually be a R enantiomer instead of S enantiomer which is levobupivacaine) Thanks! And congrats on the good work btw. :) Ld99 11:23, 18 May 2006 (UTC)

Thanks for the heads up. I checked the structure and it does appear to be correct according to PubChem and the IUPAC name function in ChemDraw. The image in the PI is indeed a mirror image, meaning that the bond changes from "pointing out" (as in the PI) to "pointing in" (as in this image) without changing chirality. -Techelf 12:49, 18 May 2006 (UTC)

Thank you for your reply. Excuse me for being ignorant here, but in your picture, with respect to the chiral carbon, is the bond pointing out or in? I have always thought the "broad" end of the bond is always more closer to the viewer than the "narrow" or "sharp" end of the bond. So in my mind, when I look at your image, I regard the NHCO side of levobupivacaine to be closer to the viewer, relative to the chiral carbon. Or could it be that because the bond is drawn in I wish I could say this more elegantly... I hope you know what I am talking about. Ld99 06:35, 24 May 2006 (UTC)

The representation of stereochemistry in structural diagrams can be a bit confusing sometimes. The convention is that solid "wedges" point out of the page, and dashed "wedges" point into the page. The "direction" of the wedge indicates the position of the chiral centre – the broad end is the end further away from the chiral centre. For example, morphine has substituents pointing in and out of the page. -Techelf 08:25, 24 May 2006 (UTC)

Thank you so much for clearing that up. I have gotten it so ridiculously wrong that I really had to laugh. Thanks again. Ld99 15:32, 26 May 2006 (UTC)

[edit] Dihydrocodeine

I sort of get your aim in edit re equal potency - but surely it is equal potential effectiveness not potency. Dihydrocodeine is broken down to codeine, so yes a pain may just as equally be treatd with dihydrocodeine as codeine itself. However there is a difference in pharmacological properties, namely that only half the amount of dihydrocodeine needs be taken for the equivalent amount (and thus effect) of codeine itself. So a dose of co-codamol 8/500 (codeine 8mg paracetamol 500mg) will provide less codeine than co-dydramol 10/500 (dihydrocodeine 10mg paracetamol 500) which has equivalent of 20mg codeine. Likewise co-codamol 30/500 (codeine 30mg paracetamol 500mg) will provide less codeine than co-dydramol 20/500 (dihydrocodeine 20mg paracetamol 500) which provides equivalent of 40mg codeine. This is similar to calculations for diamorphine and morphine - both provide equal ability to treat pain, just diamorphine needs half the quantity of morphine (as doubles up upon being slit). I agree original confusing, but still needs better explanation. David Ruben ^Talk 16:19, 26 May 2006 (UTC)

Hi, thanks for the message about dihydrocodeine. I'm actually not very familiar with the analgesic use of dihydrocodeine (it's not used for that indication in Australia), and just took the BNF and Martindale statements of "similar potency" at face value. Might you be able to clarify it on the dihydrocodeine page? Cheers. -Techelf 00:36, 27 May 2006 (UTC)

[edit] Orphaned fair use image (Image:M2mwy logo.jpeg)

This media may be deleted.

Thanks for uploading Image:M2mwy logo.jpeg. I notice the 'image' page currently specifies that your image can be used under a fair use license. However, the image is currently orphaned, meaning that is not used in any articles on Wikipedia. If your image was previously in an article, please go to the article and see why your image was deleted. You may add it back if you think that that will be useful.

If you have uploaded other fair use media, please check whether they're used in any articles or not. You can find a list of 'image' pages you have edited by clicking on the "my contributions" link (it is located at the very top of any Wikipedia page when you are logged in), and then selecting "Image" from the dropdown box. Note that any fair use images not used in any articles will be deleted after seven days, as described on criteria for speedy deletion. Thank you. Sue Anne 22:25, 28 May 2006 (UTC)

Hi Sue Anne, I agree that it meets the criteria for speedy deletion, so please delete the image – it was uploaded in error anyway. Cheers. -Techelf 11:06, 29 May 2006 (UTC)

[edit] Template

I really loved your new design at Template:Drugbox. Would you mind looking at Template:Protein? It needs a redesign, and it could use your touch. --Arcadian 01:55, 29 May 2006 (UTC)

Hi Arcadian, sorry I haven't had time to look at the template. I had a look at your recent updates and they look good, even if they strongly resemble Template:Drugbox =). Cheers. -Techelf 12:26, 1 June 2006 (UTC)

Thanks. Don't think of it as plagiarism of your template design, think of it as an homage to your talent! :) --Arcadian 13:41, 1 June 2006 (UTC)

[edit] Metroad markers

Just so you know - the Brisbane pages need some work (only Metroad 5 exists atm). As part of this, the current markers shown on the pages are for some reason incorrect (the hexagon is 'flat'). The markers on the Sydney pages are accurate and as they are identical to Brisbane 1-6, I shall use them there. Any objections? SM247 03:14, 30 May 2006 (UTC)

Hi SM247, no worries =). By the way, are there any more Brisbane place names to add to Australian English vocabulary#Place names? Cheers. -Techelf 08:19, 30 May 2006 (UTC)

[edit] Cephalosporin template

Thanks for the changes you made to the cephalosporin template. It looks a lot better in extra-small. I'm not a pharmacist, so I just copied the drugs listed in the main cephalosporin article as-is without taking responsibility for checking them all. I'm surprised that you removed loracarbef, though. Is it really not a cephalosporin? What is it, then?

I always thought that it was a cephalosporin because, due to an allergic reaction to it, I was told to avoid cephalosporins (but not all β-lactam drugs, because I've never had a problem with penicillins). Was the removal of loracarbef in error, or is not a cephalosporin but close enough to them (but not to penicillins) that my risk is from the possibility of cross-sensitivity?

I guess a normal person would be content with a yes/no for "was that correct", and I hope it doesn't seem like I'm questioning your knowledge of your own profession! I don't mean it like that at all! It's just that I'm about to start college and plan to study biology, so I'm insanely curious about medicine-related fields. Obviously if you're busy you can just say "Yes, I'm right" or "Whoops, I didn't mean to remove that one", but I'm still curious :-) --Icarus 22:31, 10 June 2006 (UTC)

Hi Icarus, the grouping of cephems (including cephalosporins) can be a bit of a mess – I've been trying to sort it out a bit on the cephalosporin page but haven't quite finished. Loracarbef is a carbacephem (carbacephems have a subtle modification to the cephalosporin nucleus), but for all intents and purposes is very similar to the second-generation cephalosporins such as cefaclor. It's similar enough that cross-reactivity occurs, but not technically a cephalosporin. Hope that helps and thanks for your work on the template. -Techelf 00:08, 11 June 2006 (UTC)

[edit] Beclomethasone and Beclomethasone propionate

Techelf, i don't know why you pharmacists have decided to use one name for these two clearly distinguishable chemicals - Beclomethasone (not Beclometasone - DrugBank shows "Beclomethasone" as a serach result for "Beclometasone"; the PubChem entry for "Beclomethasone" has lower number that the one for Beclometasone, which means that is has been added to the database earlier) and Beclomethasone propionate - is it becasue they have identical pharmacological effects or that Beclomethasone propionate as soon as it enteres the body is metabolized to Beclomethasone and that's why from drug point of view its propionate moieties are irelevant, i have no idea these are just my guesses, all i know is that any drug before being a DRUG is a chemical compound with its own properties - physical, chemical, pharmacological, etc. I would suggest you go back and revert your changes and write a good explanation about why "Beclamethasone dipropionate" is called "Beclomethasone" by you and your brethren. -- Boris 01:10, 16 June 2006 (UTC)

Thanks for the message. I hadn't actually given much thought to the dipropionate ester issue, but you're correct that they are two distinct molecules. Accordingly, I have changed the article back to "beclometasone dipropionate" (and added an explanation to the talk page) to avoid ambiguity. By the way, it's not just "us" pharmacists that call it that – "beclometasone" is the International Nonproprietary Name specified by the World Health Organization. -Techelf 10:48, 16 June 2006 (UTC)

Hmmm, what is the name for Beclomethasone/Beclometasone according to INN then? What a mess!!! Anyway. Cheers. -- Boris 00:43, 17 June 2006 (UTC)

[edit] Naproxen schedules

Hi there, I was recently editing the Naproxen article and stumbled upon a doubt I couldn't clarify. If memory serves, I believe naproxen is classified under several different Schedules in Australia, depending on the dose and the amount of units (tablets etc.) provided in the package. I was wondering if you could clarify this. Also, if this is in fact true, how would you input this information into the Drugbox? Thanks in advance, Fvasconcellos 15:27, 18 June 2006 (UTC)

Hi Fvansconcellos. Yep, that's right – naproxen can be S2 or S4 depending on the tablet strength and packet size. Cheers. -Techelf 10:57, 19 June 2006 (UTC)

Thanks for clearing that up. By the way, hope you won't mind if I start using your standardized scheduling abbreviations on Drugboxes. Fvasconcellos 18:26, 19 June 2006 (UTC)

[edit] Drug legal status

Hi - following your nice table of categorisations for Austraiia, UK & US on Template talk:Drugbox#Proposal for standard abbreviations, I had a go at the coding - see Template talk:Add_code (first example on the page). legal_AU, legal_US & legal_US are used and legal_status is still allowed (for backwards compatability for current articles that only define this and also in the future as free text to the fixed-options of teh country specific legal_XX.

Hence:  | legal_UK=POM | legal_US=Rx | legal_status=Banned in Russia
Gives:  POM(UK) Rx(US) Banned in Russia

Its a bit of a major alternative method of filling in the template, so a vote of approval, as well as confirmation of selecting the paramater names (as discussed on the template talk page) would be appreciated. David Ruben ^Talk 03:22, 16 July 2006 (UTC)

No worries, I've added a comment to the Talk page. Cheers. -Techelf 10:41, 16 July 2006 (UTC)

[edit] Copyright notification

Hi, Techelf! I've been looking on the Wikipedia:Mirrors_and_forks page, and I've noticed that yahoo's been rejecting infringement notices on meds4dumbbells.com because none of the copyright holders have sent violation notices. Just thought you might be interested in pursuing this if you have the time. The site's listing on WP:Mirrors_and_forks An example infringing page --Utopianfiat 19:41, 4 August 2006 (UTC)

[edit] Image:Nizatidine.png

The structure in you image had one extra C atom between the nitro group and the other two Ns at the right end of the molecule (drawn as "CH" right next to the nitro group), when you fixed that then replace my image with yours. -- Boris 10:22, 5 September 2006 (UTC)

[edit] Drawing chemical structures

Hi! I saw that you have created the losartan structure image with ChemDraw. The lines are very even and smooth. I use ChemDraw, but the structures I make do not have smooth lines and the bond lines appear pixalated. Can you tell me how did you manage to create such a fine image? What steps did you follow? Thanks! Tavilis 21:08, 18 September 2006 (UTC)

Hi Tavilis, not sure if you've already figured out your own method, but the process I use for preparing structural images is to create the sketch in ChemDraw, copy and paste into Macromedia Fireworks, then resize the image (bicubic resample) to a more manageable size to upload. I'm sure it'd work with any other graphics package too – I use Fireworks out of habit. Cheers. -Techelf 06:52, 15 October 2006 (UTC)