Succinyl-CoA

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Succinyl-Coenzyme A, generally abbreviated as Succinyl-CoA is a combination of succinic acid and coenzyme A.

Contents 1 Source 2 Fate 3 Formation 4 See also

[edit] Source

It is an important intermediate in the citric acid cycle, where it is synthetised from α-Ketoglutarate by α-ketoglutarate dehydrogenase through decarboxylation. During the process, coenzyme A is added.

It is also synthetised from propionyl CoA, the odd numbered fatty acid which cannot undergoes beta-oxidation. Propionyl-CoA is carboxylated to D-methylmalonyl-CoA, isomerised to L-methylmalonyl-CoA, and rearranged to yield succinyl-CoA via a vitamin B12-dependent enzyme. Succinyl-CoA is an intermediate of the citric acid cycle and can be readily incorporated there.

[edit] Fate

It is converted into succinate through the hydrolytic release of coenzyme A by succinyl-CoA synthetase (succinate thiokinase).

Another fate of succinyl-CoA is porphyrin synthesis, where succinyl-CoA and glycine are combined by ALA synthase to form δ-aminolevulinic acid (dALA).

[edit] Formation

Succinyl CoA can be formed from methylmalonyl CoA through the utilization of deoxyadenosyl-B12 (deoxyadenosylcobalamin) by methylmalonyl CoA Mutase. This reaction, which requires vitamin B12 to occur, is important in the catabolism of some branched-chain amino acids as well as odd-chain fatty acids.

[edit] See also