Sodium stibogluconate

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Image:Sodium stibogluconate.png
Sodium stibogluconate
Systematic (IUPAC) name
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ATC code	P01 CB02
PubChem	5311441
Chemical data
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Pharmacokinetic data
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Therapeutic considerations
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Sodium stibogluconate is a medicine used to treat leishmaniasis and is only available for administration by injection. It belongs to the class of medicines known as the pentavalent antimonials. Sodium stibogluconate is sold in the UK as Pentostam® (manufactured by GlaxoSmithKline).

1 Dosing
2 Side effects
3 Notes
4 References

[edit] Dosing

Sodium stibogluconate is available in the UK as Pentostam, which comes in 100 ml multi-dose glass bottles manufactured by GlaxoSmithKline. It can be diluted with 5% dextrose if necessary for ease of administration. It is available in the U.S. on a named-patient basis from the CDC.

The dose of sodium stibogluconate is 20 mg/kg per day given by slow intravenous injection (at least 5 minutes with cardiac monitoring). The injection should be stopped if there is coughing or central chest pain.

The maximum licensed dose is 850 mg per day, but most authorities now agree that there should be no maximum.^[1]

The duration of treatment is usually 10 to 21 days and depends on the species of Leishmania and the type of infection (cutaneous or visceral). The advice of a specialist should always be sought.

[edit] Side effects

Sodium stibogluconate is exceedingly phlebotoxic. One of the practical problems is that after a few doses it can become exceedingly difficult to find a vein in which to inject the drug. The insertion of a PICC does not prevent the problem and can instead make it worse: the entire vein along the course of the PICC line can become inflamed and thrombose.

Pancreatitis is a common problem and the serum amylase or lipase should be monitored twice weekly; there is no need to stop treatment if the amylase remains less than four times the upper limit of normal; if the amylase rises above the cut-off then treatment should be interrupted until the amylase falls to less than twice the upper limit of normal, whereupon treatment can be resumed. Cardiac conduction disturbances are less common, but ECG monitoring while the medicine is injected is advisable and quickly reverse after the drug is stopped or the infusion rate is decreased.

The drug can be given intramuscularly but is exceedingly painful when given by this route. It can also be given intralesionally when treating cutaneous leishmaniasis (i.e., injected directly into the area of infected skin) and again, this is exceedingly painful and does not give results superior to intravenous administration.

Sodium stibogluconate can also cause a reduced appetite, nausea, vomiting, diarrhoea, headache, tiredness, joint pains, muscle aches, dizziness, and anaphylaxis.