Sertaconazole

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Sertaconazole
Systematic (IUPAC) name
1-[2-[(7-chlorobenzothiophen-3-yl) methoxy]- 2-(2,4-dichlorophenyl)- ethyl] imidazole
Identifiers
CAS number	99592-32-2
ATC code	D01 AC14
PubChem	65863
DrugBank	APRD00305
Chemical data
Formula	C₂₀H₁₅N₂Cl₃O S
Mol. weight	437.77 g/mol
Pharmacokinetic data
Bioavailability	Negligible
Protein binding	>99% to plasma
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Licence data	US
Pregnancy cat.	C(US)
Legal status	℞ Prescription only
Routes	Topical

Sertaconazole nitrate (Ertaczo®) is an antifungal medication of the imidazole class. It is available as a cream to treat skin infections such as athlete's foot.

1 Mechanism of action
2 Microbiology
- 2.1 Susceptible organisms
3 Side effects
4 External links

[edit] Mechanism of action

The mechanism of action of sertaconazole is not fully understood. It is believed that, as all imidazole antifungals, sertaconazole inhibits the synthesis of ergosterol by the fungal cell. Ergosterol is a key component of the cell membrane of fungi, and lack of this component leads to leakage of the cell contents and ultimately to cell death.

[edit] Microbiology

[edit] Susceptible organisms

Trichophyton rubrum
Trichophyton mentagrophytes
Epidermophyton floccosum

[edit] Side effects

Side effects were rarely reported with sertaconazole therapy, but may include contact dermatitis, burning on application site and skin dryness.

[edit] External links

Ertaczo prescribing information

Antifungals (D01 and J02) edit
Antibiotics:	Griseofulvin, Hitachimycin, Natamycin, Nystatin
Topical Azoles:	Clotrimazole, Econazole, Fluconazole, Ketoconazole, Miconazole, Oxiconazole, Sertaconazole, Sulconazole, Tioconazole
Other topicals:	Ciclopirox, Ethylparaben, Flucytosine, Salicylic acid, Selenium sulfide, Terbinafine, Tolnaftate
For systemic use:	Amphotericin B, Anidulafungin, Caspofungin, Griseofulvin, Itraconazole, Terbinafine, Voriconazole
Other:	Posaconazole, Thiabendazole, Tea tree oil