Separase

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Separase is a cysteine protease (EC 3.4.22.49) responsible for triggering anaphase by hydrolysing cohesin which is the protein responsible for binding sister chromatids during metaphase.

When the cell is not dividing, separase is prevented from cleaving cohesin through its association with another protein, securin. On the signal for anaphase, the securin is ubiquitinated and hydrolysed, releasing active separase.

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Separase
Gene code: [1] ID#AAB03897.1
Structure: Unknown
Recent publications: [2]Requirement for ESP1 in the nuclear division of Saccharomyces cerevisiae.,
[3]

An ESP1/PDS1 complex regulates loss of sister chromatid cohesion at the metaphase to anaphase transition in yeast.,
[4]Sister-chromatid separation at anaphase onset is promoted by cleavage of the cohesin subunit Scc1.,

[5]A novel role of the budding yeast separin Esp1 in anaphase spindle elongation: evidence that proper spindle association of Esp1 is regulated by Pds1.
Taxa expressing: Eukaryotes
Cell types: all
Subcellular localization: Nucleus
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