SDHD

From Wikipedia, the free encyclopedia

SDHD, which stands for succinate dehydrogenase complex subunit D, is one of the two transmembrane subunits of the four-subunit succinate dehydrogenase protein complex that resides in the inner mitochondrial membrane. It also refers to the gene that codes for this protein. The other transmembrane subunit is SDHC. SDHD/SDHC are connected to the SDHB electron transfer subunit. SDHB in turn transfers electrons from the SDHA subunit to the SDHC/SDHD dimer.

Succinate dehydrogenase is an important enzyme in both the citric acid cycle and the electron transfer chain

The SDHD gene is located on chromosome 11, at locus 11q23. Names previously used for SDHD were PGL and PGL1.

[edit] Role in Disease

Mutations in the SDHD gene can cause familial paraganglioma.

Germline mutations in SDHD were first linked to hereditary paraganglioma in 2000 ^[1]. Since then, it has been shown that mutations in SDHB and to a lesser degreee SDHC can cause paranglioma as well familial pheochromocytoma. Notably, the tumor spectrum is different for the different mutations. SDHB mutations often lead to metastatic disease that is extra-adrenal, while SDHD mutation related tumors are more typically benign, originating in the head and neck.

The exact mechanism for tumorigenesis is not determined, but is is suspected that malfunction of the SDH complex can cause a hypoxic response in the cell that leads to tumor formation. People living at higher altitudes (for example, the Andes mountains) are known to have an increased rate of benign paraganglioma, with the rate of disease increasing with the altitude of the poplulation.