Rolipram

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Rolipram chemical structure
Rolipram
Systematic (IUPAC) name
4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrolidin-2-one
Identifiers
CAS number 61413-54-5
ATC code  ?
PubChem 5092
DrugBank EXPT00228
Chemical data
Formula C16H21NO3 
Mol. weight 275.347 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?
Legal status
Routes  ?

Rolipram is a PDE4-inhibitor. Like most PDE4-inhibitors, it is an anti-inflammatory drug.[1] Rolipram is being researched as a possible alternative to current antidepressants.[2][3] A recent study shows that rolipram may have antipsychotic effects.[4]

[edit] References

  1. ^ Griswold DE, Webb EF, Breton J, White JR, Marshall PJ, Torphy TJ. (1993). "Effect of selective phosphodiesterase type IV inhibitor, rolipram, on fluid and cellular phases of inflammatory response.". Inflammation. 17 (3): 333–44. PMID 7687237.
  2. ^ Bobon D, Breulet M, Gerard-Vandenhove MA, Guiot-Goffioul F, Plomteux G, Sastre-y-Hernandez M, Schratzer M, Troisfontaines B, von Frenckell R, Wachtel H. (1988). "Is phosphodiesterase inhibition a new mechanism of antidepressant action? A double blind double-dummy study between rolipram and desipramine in hospitalized major and/or endogenous depressives.". Eur Arch Psychiatry Neurol Sci. 238 (1): 2–6. PMID 3063534.
  3. ^ Wachtel H. (1983). "Potential antidepressant activity of rolipram and other selective cyclic adenosine 3',5'-monophosphate phosphodiesterase inhibitors.". Neuropharmacology. 22 (3): 267–72. PMID 6302550.
  4. ^ Kanes SJ, Tokarczyk J, Siegel SJ, Bilker W, Abel T, Kelly MP. (2006). "Rolipram: A specific phosphodiesterase 4 inhibitor with potential antipsychotic activity.". Neuroscience. ? (?): ?. PMID 17081698.
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Selective Phosphodiesterase inhibitors (C01CE, G04BE)edit
PDE1:

Vinpocetine
PDE2:

EHNA
PDE3:

Amrinone, Bucladesine, Enoximone, Milrinone
PDE4:

Rolipram
PDE5:

Sildenafil, Tadalafil, Vardenafil
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