Rocuronium

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Rocuronium
Systematic (IUPAC) name
[3-hydroxy-10,13-dimethyl-2-morpholin-4-yl-16- (1-prop-2-enyl-2,3,4,5-tetrahydropyrrol- 1-yl)- 2,3,4,5,6,7,8,9,11,12,14,15,16,17- tetradecahydro-1H-cyclopenta[a] phenanthren- 17-yl] acetate
Identifiers
CAS number	119302-91-9
ATC code	M03AC09
PubChem	7980535
DrugBank	APRD01221
Chemical data
Formula	C32H53N2O4+
Mol. weight	529.774 g/mol
Pharmacokinetic data
Bioavailability	100% (IV)
Protein binding	~30%
Metabolism	some de-acetylation
Half life	66-80 minutes
Excretion	unchanged in bile & urine
Therapeutic considerations
Pregnancy cat.	?
Legal status	POM (UK)
Routes	IV

Rocuronium is an aminosteroid non-depolarizing (that is, it does not cause initial stimulation of muscles before weakening them) neuromuscular blocker or muscle relaxant used in modern anaesthesia, to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation.

It is a more recent member of a family of similar drugs. It has rapid onset, and intermediate duration of action. It is marketed under the trade name of Zemuron ® in the United States and Esmeron ® in most other countries.

There is considered to be some risk of allergic reaction to the drug in occasional patients, but, a similar incidence of allergic reactions has been observed by using other members of the drug class (non-depolarizing neuromuscular blocking drugs). The drug is commonly used in modern anaesthesia.

The γ-cyclodextrin sugammadex has been recently introduced as a novel agent to reverse the action of rocuronium.

Muscle relaxants (M03) edit
Peripherally acting:	Alcuronium, Atracurium, Cisatracurium, Dimethyltubocurarine, Doxacurium chloride, Fazadinium bromide, Gallamine, Hexafluronium, Mivacurium chloride, Pancuronium, Pipecuronium bromide, Rocuronium bromide, Suxamethonium, Tubocurarine, Vecuronium
Centrally acting:	Baclofen, Carisoprodol, Chlormezanone, Chlorzoxazone, Cyclobenzaprine, Febarbamate, Mephenesin, Methocarbamol, Orphenadrine, Phenprobamate, Phenyramidol, Pridinol, Styramate, Tetrazepam, Thiocolchicoside, Tizanidine, Tolperisone
Directly acting:	Dantrolene