Robinson-Gabriel synthesis

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The Robinson-Gabriel synthesis is a chemical reaction that forms oxazoles by dehydration of 2-acylamino-ketones.

The Robinson-Gabriel synthesis

Historically, the dehydration agent is concentrated sulfuric acid. Recently, phosphorus oxychloride is successful with this reaction also.

2-Acylamino-ketones can be synthesized using the Dakin-West reaction.

[edit] References

  • Robinson, R. J. Chem. Soc. 1909, 95, 2167.
  • Gabriel, S. Ber. 1910, 43, 134.
  • Gabriel, S. Ber. 1910, 43, 1283.
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