Rhodanase
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Rhodanase (also Rhodanese, Thiosulfate Sulfurtransferase, Thiosulfate cyanide Transsulfurase; is a mitochondriales enzyme, which is trasferred through sulfur of [Thiosulfate]] (S 2 O 3 -2) on cyanide (CN-). Thus the latter becomes Rhodanide (Thiocyanat, SCN -), while the Thiosulfate to sulfite (SO 3 -2) one reduces.
This reaction takes place in two steps. The diagram shows the radiographically determined structure of Rhodanase. Therein one can easily recognize a connection in the catalytic center of the enzyme. This is formed in the first step, by a , here Thiosulfat, its sulfur on Thiol group Cysteins-247-Restes 1 under education Disulfans 2 transfers. In the second step under recovery of the "normal" Thiol group the substrate, here cyanide, is sulfidiert:
This reaction is important for the decontamination of taken up cyanide, since the developing Thiocyanat is as far as possible innocuous. The administration of Thiosulfat (e.g. in form of one [ [ Natriumthiosulfat]] solution) with cyanide poisonings is based also on the activation of this enzymatic decontamination system. Vordergruendig seems to be this reaction the actual task of the Rhodanase; over its actual meaning so far no clarity prevails. A role as Schwefeldonor with the synthesis of [ [ iron sulfur Cluster]]n for [ [ iron sulfur proteins ] ] is discussed.
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Kategorie:Biochemistry Kategorie:Biomolecule Kategorie:Enzyme
