Reverse tolerance

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Reverse tolerance is the phenomenom of a reversal of the side-effects from a drug, or the reduction of insensitivity caused by repeated use of the drug (see tolerance). Typically this involves the use of an additional medication, or abstinence from a drug for a period of time, known as a drug holiday. Such drugs include amphetamines, or SSRIs.[1][2] As a result, regular users commonly experience a quick decrease of unwanted side effects, without an equivalent loss of its stimulant properties. Notably, the sensitization is induced more quickly, and persists far longer than withdrawal-related effects, suggesting a phenomenon more complex than a simple tolerance-induced withdrawal syndrome.

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[edit] References

  1. ^ Leith N, Kuczenski R (1981). "Chronic amphetamine: tolerance and reverse tolerance reflect different behavioral actions of the drug.". Pharmacol Biochem Behav 15 (3): 399-404. PMID 7291243.
  2. ^ Chaudhry I, Turkanis S, Karler R (1988). "Characteristics of "reverse tolerance" to amphetamine-induced locomotor stimulation in mice.". Neuropharmacology 27 (8): 777-81. PMID 3216957.
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