Reprimo

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The gene reprimo has been found to be downregulated in several cancers but rarely in healthy cells. Its role appears to be related to its interaction with p53 (tumor protein 53). The gene is methylated, sometimes in pre-cancerous growths and may be an early cancer indicator. 1

[edit] Reference

  • Note 1: Takahashi T, Suzuki M, Shigematsu H, Shivapurkar N, Echebiri C, Nomura M, Stastny V, Augustus M, Wu CW, Wistuba II, Meltzer SJ, Gazdar AF (2005). "Aberrant methylation of Reprimo in human malignancies". International Journal of Cancer 115 (4): 503-10. PMID 15700311.


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