RecA
From Wikipedia, the free encyclopedia
recA is a 38 kilodalton Escherichia coli protein essential for the repair and maintenance of DNA. RecA has a structural and functional homolog in every species in which it has been seriously sought and serves as an archetype for this class of homologous DNA repair proteins. The homologous protein in Homo sapiens is called RAD51.
RecA has multiple activities, all related to DNA repair. In the bacterial SOS response, it has a co-protease function in the autocatalytic cleavage of the LexA repressor and the λ repressor. Its most studied role is in facilitating DNA recombination for the repair of double strand DNA breaks and the exchange of genetic information through sexual reproduction.
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