Rasburicase
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Rasburicase
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| Systematic (IUPAC) name | |
| Aspergillus urate oxidase | |
| Identifiers | |
| CAS number | 134774-45-1 |
| ATC code | V03AF07 |
| PubChem | ? |
| DrugBank | BIOD00090 |
| Chemical data | |
| Formula | C1521H2381N417O461S7 |
| Mol. weight | 34109.5 |
| Pharmacokinetic data | |
| Bioavailability | N/A |
| Metabolism | ? |
| Half life | 8 hrs |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status |
RX/POM |
| Routes | Intravenous |
Rasburicase (brand names: Fasturtec and Elitek) is a recombinant urate oxidase enzyme. It is used for the prevention and treatment of tumor lysis syndrome in patients receiving chemotherapy for hematologic cancers such as leukemias and lymphomas.
It catalyses the conversion of uric acid to allantoin. Allantoin is much more soluble than uric acid, so renal excretion is more effective.
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