RANTES
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| The structure of human RANTES | |
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chemokine (C-C motif) ligand 5
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| Identifiers | |
| Symbol(s) | CCL5 D17S136E, SCYA5 |
| Entrez | 6352 |
| OMIM | 187011 |
| RefSeq | NM_002985 |
| UniProt | P13501 |
| PDB | 1PMI |
| Other data | |
| Locus | Chr. 17 q11.2-q12 |
Regulated upon Activation, Normal T-cell Expressed, and Secreted or RANTES is an 8kDa protein classified as a chemotactic cytokine or chemokine. It has recently been renamed CCL5.
RANTES is chemotactic for T cells, eosinophils and basophils and plays an active role in recruiting leukocytes into inflammatory sites. With the help of particular cytokines (i.e. IL-2 and IFN-γ) that are released by T cells, RANTES also induces the proliferation and activation of certain natural killer (NK) cells to form CHAK (CC-Chemokine-activated killer) cells.[1] It is also a HIV-suppresive factor released from CD8+ T cells.
[edit] See also
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