RANKL
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RANKL stands for Receptor Activator for Nuclear Factor κ B Ligand. This natural and necessary messenger molecule activates osteoclasts, cells involved in bone resorption. Overproduction of RANKL is implicated in a variety of degenerative bone diseases, like rheumatoid arthritis.
Reference: MP Whyte. The Long and the Short of Bone Therapy, NEJM, 354:860-863.
