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In Rocko's Modern Life, Ralph is Ed and Bev Bighead's son. He was disowned by Ed for not wanting to work for Conglom-O, so he went to Holl-o-Wood to become a cartoonist. However, in a later episode, he and Ed finally reunited and ended their feud. He created a cartoon called The Fatheads (a married couple based loosely on his parents). In an attempt to get out of his career as a cartoonist, Ralph also created the intentionally bad cartoon Wacky Delly to have it immediately cancelled (Instead, the show became a runaway hit, much to his dismay). Creator Joe Murray does the voice of Ralph.
[edit] Trivia
Mr. Lawrence and Martin Olson convinced Joe Murray to voice Ralph Bighead, a cartoonist character through which Murray satirized himself.