Radioligand

From Wikipedia, the free encyclopedia

A radioligand is a radioactive biochemical substance (in particular, a ligand) that is used for diagnosis or for research-oriented study of the receptor systems of the body.

The radioligand is injected into the pertinent tissue, or infused into the bloodstream. It binds to its receptor. When the radioactive isotope in the ligand decays it can be measured, e.g., by positron emission tomography.

The transport of the radioligand is described by receptor kinetics.

Contents 1 Radioactive isotopes commonly used 2 List of radioligands 3 See also 4 References

[edit] Radioactive isotopes commonly used

• Tritium ³H
• Carbon-14
• Sulfur-35
• Iodine-131

[edit] List of radioligands

• (¹⁸F)altanserin^[1]
• (¹¹C)ketanserin ^{[citation needed]}

[edit] See also

• Binding potential
• Distribution volume

[edit] References

1. ^ Karen H. Adams, Lars H. Pinborg, Claus Svarer, S. G. Hasselbalch, Søren Holm, Steven Haugbøl, K. Madsen, Vibe G. Frøkjær, L. Martiny Olaf B. Paulson, Gitte Moos Knudsen, A database of [¹⁸F]-altanserin binding to 5-HT_2A receptors in normal volunteers: normative data and relationship to physiological and demographic variables, NeuroImage, 21(3):1105-1113, 2004 March.