Quinapril
From Wikipedia, the free encyclopedia
 |
|
|
Quinapril
|
|
| Systematic (IUPAC) name | |
| (3S)-2-[(2S)-2-[[(1S)-1-ethoxycarbonyl-3-phenyl- propyl]amino]propanoyl]-3,4-dihydro-1H-isoquinoline- 3-carboxylic acid |
|
| Identifiers | |
| CAS number | 85441-61-8 |
| ATC code | C09AA06 |
| PubChem | 54892 |
| DrugBank | APRD00523 |
| Chemical data | |
| Formula | C25H30N2O5 |
| Mol. weight | 438.516 g/mol |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Protein binding | 97% |
| Metabolism | ? |
| Half life | 2 hours |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
D |
| Legal status |
℞ Prescription only |
| Routes | ? |
Description
Quinapril (Quinapril Hydrochloride marketed as brand of Pfizer Accupril®) is an angiotensin-converting enzyme (ACE) inhibitor.
Mechanism of Action
Quinapril is the prodrug, it deesterified inside an organism and formed active metabolite quinaprilat. Quinaprilat competitively inhibits transformation of angiotensin I to angiotensin II and reduce the concentration of angiotensin II in blood. In the result the concentration of aldosterone (which secretion stimulated by angiotensin II) reduce too and the secondary plasma renin activity (PRA) increase.
Indications and Usage of Quinapril (Accupril®)
- High blood pressure (Hypertension)
- Chronic Heart Failure (in combination with diuretics and/or digitalis)
Contraindications
- Pregnancy
- Impaired renal and liver function
- Patients with a history of angioedema related to previous treatment with an ACE inhibitor.
- Hypersensitive to Quinapril
Side effects of Quinapril (Accupril®)
- dizziness
- cough
- vomiting
- upset stomach
- excessive tiredness
[edit] External links
| ACE inhibitors (C09A) edit | ||
|---|---|---|
|
Benazepril, Captopril, Enalapril, Fosinopril, Lisinopril, Perindopril, Quinapril, Ramipril, Spirapril, Trandolapril |
||
