Talk:Pyruvate decarboxylation
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ATTN: ANYONE WITH BIOLOGICAL KNOWLEDGE!
I am a college student in BIO 223, and I would like to know if anyone reading this article can give me some feedback on whether or not any ATP is produced (in addition to the 2 acetyl molecules, the 2 NADH, & the 2 carbon dioxides) during this period of cellular respiration?
- Not directly. But the NADH can go onto provide about 3 ATP via oxidative phosphorylation. David D. (Talk) 16:06, 31 January 2006 (UTC)
Also, does anyone know why this stage is not included in the biological courses of some professors as a major part of cellular respiration?
- It usually is, you were never told where most of the acetyl CoA came from that enters the Krebs cycle? Another source of acetyl CoA is from beta oxidation of fatty acids. David D. (Talk) 16:06, 31 January 2006 (UTC)
Any helpful insight would be much appreciated... (Just post it under discussion & I will check back in few days to see if anyone has posted a response.) Thanks again.
Also: Are there any really detailed, informative, and reliable sites that I could visit that provide biologically pertinent information? I really need all the help I can get for this course. Thanks.
- The best cite is Kimball's biology pages. They are up to date and by far the most accurate available. David D. (Talk) 16:06, 31 January 2006 (UTC)
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[edit] Finding this page
Hopefully this page is now more findable! I have added the reaction to the end of glycolysis and will be adding it to the start of the citric acid cycle, although according to the KEGG pathway database this reaction doesn't technically belong to either pathway.
This reaction does belong in the aerobic respiration 'pathway' and is clearly linked from there.
This page is also reached by redirection from "the link reaction" and "link reaction".
[edit] The name "Oxidative decarboxylation"
I have never heard this step called Oxidative decarboxylation. The living world 4th ed. by George Johnson lists this step as "Pyruvate Oxidation", however, most texts just include it in the citric acid cycle or call it the "entry into the Kreb's cycle." I don't think that students will be able to find it under this name. Rozzychan
- The one thing that matters is that wikipedia is consistent. I don't have a strong preference either way but agree that pyruvate decarboxylation is more specific. At present it is quite a general title that is, nevertheless, appropraite for this reaction. David D. (Talk) 18:58, 23 June 2006 (UTC)
[edit] The pathway
This pathway really needs cleaning up on wikipedia. There needs to be a page that directly links to each step in this pathway. How exactly does one do that?
Rozzychan 18:17, 23 June 2006 (UTC)
Which pathway? This is one reaction. Do you mean cellular respiration or possibly Krebs cycle? David D. (Talk) 18:54, 23 June 2006 (UTC)
[edit] Oxidative Decarboxylation
Do NOT equal oxidative decarboxylation to the pyruvate dehydrogenase reaction since there are other types of oxidative decarboxylations, for instane 2 such oxidative decarboxylation reactions are present in the Krebs cycle, namely the reactions catalyzed by isocitrate dehydrogenase and alpha-ketoglutarate dehydrogenase.
Oxidation can be through a)addition of oxygen to a substrate or b) removal of hydrogen ions from the substrate. to put it simple
more detailed it is the loss of electrons due to the 2 afore mentioned reasons.
Since most oxidation reactions involve hydrogen removal, these paricular enzymes are called dehydrogenases, as in the case of the earlier mentioned enzymes.
Oxidative decarboxylation = Decarboxylation of a substrate involving oxidation of the substrate.
In the case of these enzymes electrons from the substrate (reductant) are transfered to a coenzyme which becomes reduced (gain electrons). During this reaction the carboxyl group tends to spontaneusly deattach from the substrate yealding CO2, hence decarboxylation.
(Matthews, Van Holde, Ahern; Biochemistry, 3rd edition Addison-Wesley Publishing Company)
