Talk:Prostaglandin
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[edit] 15PGJ2
I removed "15-Deoxy-Δ12,14-PGJ2 (15d-PGJ2)is a PGD2 derivative that acts on PPAR intracellular receptors" because this proposition has since been proven false. [1] Mazzo 01:09, 11 August 2006 (UTC)
[edit] Paturition link
I don't understand adding a Parturition link right after the childbirth one. Not only do they mean the same thing, but Parturition just gets redirected to childbirth. But I'm leaving the link in for the moment. David.Throop 15:48, 15 February 2006 (UTC)
- Childbirth commences with labour. Parturition commences with the actual moving of the child through the birth canal. In other words: if labour is not progressing to parturition, prostaglandins may be of help. JFW | T@lk 00:23, 16 February 2006 (UTC)
[edit] Enzymes
Hi,
Just to point out that the conversion of prostacyclin to both prostaglandin and thromboxane first involves the enzyme 'cyclo-oygenase' before postacyclin synthatase and thromboxane synthatase respectively.
[edit] Enzymes
The relavance of this is in the treatment fo hypertension. Drugs called NSAIDs inhibit cyclo-oxygenase. This leads to the reduced production of thromboxane (a vasoconstrictor and coagulant) but not prostacyclin as the former is produced in platelets which do not have the capacity to synthesise new cyclo-oxygenase whereas new prostacyclin can be produced by the nuclei of the endothelial cells it is produced in.
[edit] Plants prostaglandins
Prostaglandins and prostaglandin-like substances have also been found in plants. This fact maybe should be mentioned in the article. Tavilis 19:31, 8 September 2006 (UTC)
