Talk:Progesterone

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It's not clear to me why levonorgestrel redirects here. Is levonorgestrel just synthetic progesterone or is it an isomer or just similar in effect? Matt 18:13, 23 Dec 2004 (UTC)

--Levonorgestrel is a synthetic progesterone receptor agonist (aka progestin).

Contents 1 Synthesis: Conflicting Information With Testosterone Article 2 Clearer wording needed 3 "necessary to be suspicious..." deleted 4 multiple sclerosis and (not natural )progestagenes 5 membrane progesterone receptors

[edit] Synthesis: Conflicting Information With Testosterone Article

In Progesterone article: Progesterone, like all other steroid hormones, is synthesized from pregnenolone, a derivative of cholesterol.

In Testosterone article: Testosterone is synthesized from progesterone, the precursor of all steroid hormones and a derivative of cholesterol.

These appear to me to be conflicting or at least confusingly incomplete.

Progesterone is not a precursor of all steroid hormones and conflicting information seems to have been clarified.Ekem 03:28, 7 June 2006 (UTC)

[edit] Clearer wording needed

"Progesterone is thermogenic, raising the core temperature."

Could someone clarify what this is the core temperature of? It's probably referring to the body's temperature but that should be made explicit in the article. --Molimo 00:44, 12 December 2005 (UTC)

There should be a discussion on this page about the difference between biodentical human progesterone, horse progesterone, and drugs that are similar to progesterone but are not progesterone.

[edit] "necessary to be suspicious..." deleted

could have been reworded to be less subjective, but would still have been misleading. distinction between exogenous/endogenous progesterone could be made viz safety testing, with care to note major distinctions amongst exogenous progestins, i.e., 19 carbon/21 carbon (all of which carry degree of warning as carcinogens). but. as far as i know, there has been no "safety" testing on endogenous progesterone... Cindery 02:24, 13 August 2006 (UTC)

[edit] multiple sclerosis and (not natural )progestagenes

I have a feeling that worsening of my MS coincides with starting my period; which means dropping of my progestagene levels"?

There also are leads with cholesterols and multiple sclerosis, so are cholesterol and progestagene connected (synthesis). Is there a connection between low progestagenes (or relative lows on progestagenes as compared to estragens?) Why do twice as many women suffer from multiple sclerosis as do men? Does this give as a clue?

[edit] membrane progesterone receptors

A recent article about membrane progesterone receptors: "Two unrelated putative membrane-bound progestin receptors, progesterone membrane receptor component 1 (PGMRC1) and membrane progestin receptor (mPR) beta, are expressed in the rainbow trout oocyte and exhibit similar ovarian expression patterns". --JWSchmidt 05:49, 5 November 2006 (UTC)