Procyclidine hydrochloride
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| Image:Procyclidine hydrochloride.png | |
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Procyclidine hydrochloride
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| Systematic (IUPAC) name | |
| 1-cyclohexyl-1-phenyl-3-pyrrolidin-1-yl-propan-1-ol hydrochloride | |
| Identifiers | |
| CAS number | 77-37-2 |
| ATC code | N04AA04 |
| PubChem | 207841 |
| DrugBank | APRD00383 |
| Chemical data | |
| Formula | C19H30ClNO |
| Mol. weight | 323.9 g/mol |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Protein binding | ~100%-albumin |
| Metabolism | ? |
| Half life | ~12 h |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status | |
| Routes | oral, im, iv |
Procyclidine hydrochloride is an anticholinergic drug principally used for the treatment of:
- Drug-induced parkinsonism, akathisia and acute dystonia;
- Parkinson disease; and
- Idiopathic or secondary dystonia.
[edit] Uses
It is used in patients with schizophrenia to reduce the side effects of antipsychotic treatment, such as parkinsonism and akathisia.
Procyclidine is also a second-line drug for the treatment of Parkinson's disease. It improves tremor but not rigidity or bradykinesia.
Procyclidine is also sometimes used for the treatment of dystonia (but not tardive dyskinesia), a rare disorder that causes abnormal muscle contraction, resulting in twisting postures of limbs, trunk, or face.
[edit] References
- (March 2003) British National Formulary, 45.
