Prickle (protein)

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prickle-like 1 (Drosophila)
Identifiers
Symbol(s) PRICKLE1
Entrez 144165
OMIM 608500

The first prickle protein was identified in Drosophila as a planar cell polarity protein. Vertebrate prickle-1 was first found as a rat protein that binds to a transcription factor, neuron-restrictive silencer factor (NRSF). It was then recognized that other vertebrates including mice and humans have two genes that are related to Drosophila prickle[1]. Mouse prickle-2 was found to be expressed in mature neurons of the brain along with mouse homologs of Drosophila planar polarity genes flamingo and dischevelled[2].

prickle-like 2 (Drosophila)
Identifiers
Symbol(s) PRICKLE2
Entrez 166336
OMIM 608501

Prickle is recruited to the cell surface membrane by strabismus, another planar cell polarity protein[3]. In the developing Drosophila wing, prickle becomes concentrated at the proximal side of cells[3]. Prickle can compete with the ankyrin-repeat protein Diego for a binding site on Dishevelled[4].

In Drosophila, prickle is present inside cells in multiple forms due to alternative splicing of the prickle mRNA[5]. The relative levels of the alternate forms may be regulated and involved in the normal control of planar cell polarity[5].

[edit] References

  1. ^ M. Katoh and M. Katoh (2003) "Identification and characterization of human PRICKLE1 and PRICKLE2 genes as well as mouse Prickle1 and Prickle2 genes homologous to Drosophila tissue polarity gene prickle" in International Journal of Molecular Medicine Volume 11, pages 249-256. Entrez PubMed 12525887
  2. ^ F. Tissir and A. Goffinet (2006) "Expression of planar cell polarity genes during development of the mouse CNS" in The European Journal of Neuroscience Volume 23, pages 597-607. Entrez PubMed 16487141
  3. ^ a b R. Bastock, H. Strutt and D. Strutt (2003) "Strabismus is asymmetrically localised and binds to Prickle and Dishevelled during Drosophila planar polarity patterning" in Development Volume 130, pages 3007-3014. Entrez PubMed 12756182
  4. ^ A. Jenny, J. Reynolds-Kenneally, G. Das, M. Burnett and M. Mlodzik (2005) "Diego and Prickle regulate Frizzled planar cell polarity signalling by competing for Dishevelled binding" in Nature Cell Biology Volume 7, pages 691-697. Entrez PubMed 15937478
  5. ^ a b David Gubb, Clare Green, David Huen, Darin Coulson, Glynnis Johnson, David Tree, Simon Collier and John Roote (1999) "The balance between isoforms of the prickle LIM domain protein is critical for planar polarity in Drosophila imaginal discs" in Genes in Development Volume 13, pages 2315-2327. Entrez PubMed 10485852
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