Pravastatin

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Pravastatin
Systematic (IUPAC) name
3,5-dihydroxy-7- [6-hydroxy-2-methyl-8- (2-methylbutanoyloxy)- 1,2,6,7,8,8a- hexahydronaphthalen-1-yl]- heptanoic acid
Identifiers
CAS number	81093-37-0
ATC code	C10AA03
PubChem	54687
DrugBank	APRD00328
Chemical data
Formula	C23H36O7
Mol. weight	424.528 g/mol
Pharmacokinetic data
Bioavailability	?
Protein binding	50%
Metabolism	?
Half life	77 hours
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?

In medicine and pharmacology, pravastatin (Pravachol® or Selektine®) is a member of the drug class of statins, used for lowering cholesterol and preventing cardiovascular disease.

Pravastatin was identified originally in a bacterium called Nocardia autotrophica by researchers of the Sankyo Pharma Inc. It is presently being marketed outside Japan by the pharmaceutical company Bristol-Myers Squibb.

The U.S. Food and Drug Administration approved a generic version of Pravastatin for sale in the United States for the first time on April 24, 2006. Generic Pravastatin Sodium Tablets (10mg, 20mg and 40mg) are manufactured by TEVA Pharmaceuticals in Kfar Sava, Israel. FDA Press Release

In 2005, Pravachol was the 22nd highest-selling brand-name drug in the United States. FDA Press Release

[edit] External links

• Pravachol information from the National Institute of Health
• Package insert for Pravachol
• Links to external chemical sources.

Statins (C10AA) edit
Atorvastatin, Cerivastatin, Fluvastatin, Lovastatin, Mevastatin, Pitavastatin, Pravastatin, Rosuvastatin, Simvastatin