Plasminogen activator inhibitor-2
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serpin peptidase inhibitor, clade B (ovalbumin), member 2
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| Identifiers | |
| Symbol(s) | SERPINB2 PLANH2, PAI2 |
| Entrez | 5055 |
| OMIM | 173390 |
| RefSeq | NM_002575 |
| UniProt | P05120 |
| Other data | |
| Locus | Chr. 18 q21.3 |
Plasminogen activator inhibitor-2 (placental PAI) is a coagulation factor which inactivates tPA & urokinase. It is only present in relevant quantities during pregnancy, as it is produced by the placenta, and may explain partially the increased rate of thrombosis during pregnancy.
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| Coagulation factors: - Fibrin (I) - (Pro)thrombin (II) - FV - FVII - FVIII - FIX - FX - FXI - FXII - FXIII - HMWK - vWF - Tissue factor |
| Inhibitors: Antithrombin - Protein C - Protein S - Protein Z - ZPI - TFPI |
| Fibrinolysis: Plasmin - tPA/urokinase - PAI-1/2 - α2-AP - TAFI |
