Pierre Deniker

From Wikipedia, the free encyclopedia

Pierre Deniker (born 1917) was involved in the introduction of chlorpromazine (Thorazine) the first antipsychotic used in the treatment of schizophrenia, in the 1950's. Thorazine had been used in surgical procedures peri-operatively as an anti-nausea medication in France. Patients were noted to be less anxious and calmer. This observation eventually led Deniker to try chlorpromazine with patients who had schizophrenia, where he observed notable improvement in symptoms.

The pharmaceutical company Smith-Kline had purchased the chlorpromazine rights from Rhone-Poulenc in France and had been marketing it as an anti-nausea medication. After Deniker's observations, they sought and received FDA approval in 1954 to market Thorazine for the treatment of schizophrenia.