Phospholamban

From Wikipedia, the free encyclopedia

Phospholamban is a 52 amino acid integral membrane protein that regulates the Ca²⁺ pump in cardiac muscle cells.

Phospholamban is phosphorylated by Protein Kinase A, inducing an order-to-disorder transition, activating the SERCA.

[edit] References

1. Karim, C. B., T. L. Kirby, Z. Zhang, Y. Nesmelov, and D. D. Thomas. 2004. Phospholamban structural dynamics in lipid bilayers probed by a spin label rigidly coupled to the peptide backbone. Proc Natl Acad Sci USA, 101(40): 14437-14442. Entrez PubMed 15448204

[edit] External links

• Orientations of phospholamban and sarcolipin in membrane