Phenprocoumon

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Phenprocoumon chemical structure
Phenprocoumon
Systematic (IUPAC) name
2-hydroxy-3-(1-phenylpropyl)chromen-4-one
Identifiers
CAS number 435-97-2
ATC code B01AA04
PubChem 9908
DrugBank APRD00228
Chemical data
Formula C18H16O3 
Mol. weight 280.318 g/mol
Pharmacokinetic data
Bioavailability  ?
Protein binding 99%
Metabolism hepatic to inactive metabolites
Half life 5 to 6 days
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?
Legal status
Routes  ?

Phenprocoumon is a anticoagulant, functioning as a Vitamin K antagonist. It is a derivative of coumarin and is also marketed under the brand name Marcoumar. It is a vitamin K antagonist that inhibits coagulation by blocking synthesis of coagulation factors II, VII, IX and X. It is used for the prophylaxis and treatment of thromboembolic disorders.

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Antithrombotics (thrombolytics, anticoagulants, and antiplatelet drugs) (B01) edit
Vitamin K antagonists:

Acenocoumarol, Clorindione, Dicumarol (Dicoumarol), Diphenadione, Ethyl biscoumacetate, Phenprocoumon, Phenindione, Tioclomarol, Warfarin
Heparin group (Platelet
aggregation inhibitors):

Antithrombin III, Bemiparin, Dalteparin, Danaparoid, Enoxaparin, Heparin, Nadroparin, Parnaparin, Reviparin, Sulodexide, Tinzaparin
Other Platelet
aggregation inhibitors:

Abciximab, Acetylsalicylic acid (Aspirin), Aloxiprin, Beraprost, Ditazole, Carbasalate calcium, Cloricromen, Clopidogrel, Dipyridamole, Epoprostenol, Eptifibatide, Indobufen, Iloprost, Picotamide, Prasugrel, Ticlopidine, Tirofiban, Treprostinil, Triflusal
Enzymes:

Alteplase, Ancrod, Anistreplase, Brinase, Drotrecogin alfa, Fibrinolysin, Protein C, Reteplase, Saruplase, Streptokinase, Tenecteplase, Urokinase
Direct thrombin inhibitors:

Argatroban, Bivalirudin, Dabigatran, Desirudin, Hirudin, Lepirudin, Melagatran, Ximelagatran
Other antithrombotics:

Dabigatran, Defibrotide, Dermatan sulfate, Fondaparinux, Rivaroxaban
Non-medicinal:

Citrate, EDTA, Oxalate
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