Pergolide

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Pergolide
Systematic (IUPAC) name
?
Identifiers
CAS number	66104-22-1
ATC code	N04BC02
PubChem	47811
DrugBank	APRD00663
Chemical data
Formula	C19H26N2S
Mol. weight	314.489 g/mol
Pharmacokinetic data
Bioavailability	?
Protein binding	90%
Metabolism	Extensively hepatic
Half life	27 hours
Excretion	?
Therapeutic considerations
Pregnancy cat.	B
Legal status
Routes	Oral

Pergolide is an ergoline-based dopamine receptor agonist used for the treatment of Parkinson's disease.

Parkinson's disease is associated with low levels of the neurotransmitter dopamine in the brain. Pergolide has some of the same effects as dopamine in the body.

Pergolide is also used to treat the stiffness, tremors, spasms, and poor muscle control of Parkinson's disease, although it has also been used to treat discomfort or pain in the lower extremities that can only be relieved by moving the legs. Pergolide is often used in conjunction with other medicines in the treatment of Parkinson's disease.

Furthermore, Pergolide may also be used for other purposes.

In decreasing use as has been associated with fibrotic heart disease^{[citation needed]}.

Pergolide has also been shown to impair associative learning.^[1]

[edit] References

1. ^ Breitenstein C. et al. (2006): "Tonic Dopaminergic Stimulation Impairs Associative Learning in Healthy Subjects", Neuropsychopharmacology. Full text

[edit] External links

• Pergolide

Ergolines edit
Lysergic acid derivatives
Bromocriptine, Cabergoline, Ergine, Ergonovine, Ergotamine, Lysergic acid, Lysergol, d-Lysergic acid hydroxyethylamide, Lisuride, Methergine, Methysergide, Pergolide
Hallucinogenic lysergamides
AL-LAD, ALD-52, BU-LAD, CYP-LAD, DAL, DAM-57, Ergonovine, ETH-LAD, LAE-32, LSD, LPD-824, LSM-775, Methylergonovine, MLD-41, PARGY-LAD, PRO-LAD
Other ergolines
Ergoline
Natural sources
Argyreia nervosa, Claviceps spp., Ipomoea tricolor, Ipomoea violacea, Rivea corymbosa