Pemberton's sign

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Pemberton's sign is the development of facial plethora, distended neck and head superficial veins, inspiratory stridor and elevation of the jugular venous pressure (JVP) upon raising of the patient's both arms above his/her head simultaneously (Pemberton's maneuver).

A positive Pemberton's sign is a sign of superior vena cava syndrome, possibly from a mass in the mediastinum, usually caused by a tumour or struma.

H. S. Pemberton: Sign of submerged goitre. The Lancet, London, 1946, 251: 509