PDZ domain

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The PDZ domain is a common structural domain of 80-90 amino-acids found in the signaling proteins of bacteria, yeast, plants, and animals[1]. PDZ is an acronym combining the first letters of three proteins — post synaptic density protein (PSD95), Drosophila disc large tumor suppressor (DlgA), and zo-1 protein — which were first discovered to share the domain. PDZ domains are also referred to as DHR (Dlg homologous region) or GLGF (glycine-leucine-glycine-phenylalanine) domains. These domains help anchor transmembrane proteins to the cytoskeleton and hold together signaling complexes[2].

[edit] References

  1. ^ Ponting C (1997). "Evidence for PDZ domains in bacteria, yeast, and plants.". Protein Sci 6 (2): 464-8. PMID 9041651.
  2. ^ Ranganathan R, Ross E (1997). "PDZ domain proteins: scaffolds for signaling complexes.". Curr Biol 7 (12): R770-3. PMID 9382826.

[edit] External links

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