PDK1

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In biochemistry, PDK1 is a master kinase, discovered by Dario Alessi, which is crucial for the activation of AKT and many other AGC kinases. An important role for PDK1 is in insulin signalling.

  • PDK1 stands for phosphoinositide-dependent protein kinase 1.

[edit] References

  • "A phosphoserine/threonine-binding pocket in AGC kinases and PDK1 mediates activation by hydrophobic motif phosphorylation" by Morten Frödin, Torben L. Antal, Bettina A. Dümmler, Claus J. Jensen, Maria Deak, Steen Gammeltoft, and Ricardo M. Biondi in The EMBO Journal (2002) Volume 21, pages 5396–5407. Full text at PMC: 129083


[edit] External links

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