Parathyroid hormone receptor
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parathyroid hormone receptor 1
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| Identifiers | |
| Symbol(s) | PTHR1 PTHR |
| Entrez | 5745 |
| OMIM | 168468 |
| RefSeq | NM_000316 |
| UniProt | Q03431 |
| Other data | |
| Locus | Chr. 3 p22-p21.1 |
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parathyroid hormone receptor 2
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| Identifiers | |
| Symbol(s) | PTHR2 |
| Entrez | 5746 |
| OMIM | 601469 |
| RefSeq | NM_005048 |
| UniProt | P49190 |
| Other data | |
| Locus | Chr. 2 q33 |
There are two known parathyroid hormone receptors in mammals termed PTH1R and PTH2R. These receptors are members of the 7 transmembrane G protein-coupled family of receptors.
- PTH1R is the classical PTH receptor, is expressed in high levels in bone and kidney and regulates calcium ion homeostasis through activation of adenylate cyclase and phospholipase C.
- PTH2R is expressed primarily in the central nervous system, pancreas, testis, and placenta.
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