Pancreatic polypeptide

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pancreatic polypeptide
Identifiers
Symbol(s)	PPY
Entrez	5539
OMIM	167780
RefSeq	NM_002722
UniProt	P01298
Other data
Locus	Chr. 17 p11.1-qter

Pancreatic polypeptide is an polypeptide secreted by PP cells in the endocrine pancreas predominantly in head. It consists of 36 amino acids and has molecular weight about 4200 Da.

Pancreatic polypeptide is cholecystokinin antagonist. It suppresses the pancreatic secretion and stimulates gastric secretion.

Its secretions in humans is increased after a protein meal, fasting, exercise, and acute hypoglycemia and is decreased by somatostatin and intravenous glucose. The function of PP is unknown, but effects on hepatic glycogen levels and gastrointestinal secretions have been suggested.